Transmembrane Emp24 Domain-Containing Protein 7 (TMED7) Rat Recombinant Protein

Function: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted cargo including processing and post-translational modifications

By similarity.

Subunit structure: Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment and trans-Golgi network. Oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED9 and TMED10. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED7

By similarity. Ref.3

Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus › cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle › COPI-coated vesicle membrane; Single-pass type I membrane protein

By similarity. Cytoplasmic vesicle › COPII-coated vesicle membrane; Single-pass type I membrane protein

By similarity. Note: Cycles between compartments of the early secretatory pathway. Ref.3

Post-translational modification: N-linked glycosylated in complex form containing terminal sialic acid

By similarity.

Sequence similarities: Belongs to the EMP24/GP25L family.Contains 1 GOLD domain.