Major Royal Jelly Protein 1 (MRJP1) Apis Mellifera Recombinant Protein

Major royal jelly protein 1: induces the differentiation of honeybee larvae into queens through an Egfr-mediated signaling pathway. Promotes body size increase by activating p70 S6 kinase, stimulates ovary development by augmenting the titer of vitellogenin (Vg) and juvenile hormone, and reduces developmental time by increasing the activity of mitogen-activated protein kinase and inducing the 20-hydroxyecdysone protein (20E). Most abundant protein found in the royal jelly which is the food of the queen honey bee larva. The royal jelly determines the development of the young larvae and is responsible for the high reproductive ability of the honeybee queen. Jellein-1: has antibacterial activity against the Gram-positive bacteria S. aureus 6535, S. saprophyticus and B. subtilis CCT2471, and the Gram-negative bacteria E Coli CCT1371, E. cloacae 23355, K. pneumoniae 13883 and P. aeruginosa 27853, and antifungal activity against C. albicans. Lack cytolytic activity and does not induce rat peritoneal mast cell degranulation. Jellein-2: has antibacterial activity against the Gram-positive bacteria S. aureus 6535, S. saprophyticus and B. subtilis CCT2471, and the Gram-negative bacteria E Coli CCT1371, E. cloacae 23355, K. pneumoniae 13883 and P. aeruginosa 27853, and antifungal activity against C. albicans. Lack cytolytic activity and does not induce rat peritoneal mast cell degranulation. Jellein-4: lacks antibacterial and antifungal activity. Lacks cytolytic activity and does not induce rat peritoneal mast cell degranulation.

Change in the mode of gene expression of the hypopharyngeal gland cells with an age-dependent role change of the worker honeybee Apis mellifera L.Ohashi K., Natori S., Kubo T.Eur. J. Biochem. 249:797-802(1997) A hypopharyngeal gland protein of the worker honeybee Apis mellifera L. enhances proliferation of primary-cultured rat hepatocytes and suppresses apoptosis in the absence of serum.Kamakura M., Sakaki T.Protein Expr. Purif. 45:307-314(2006) Royalactin induces queen differentiation in honeybees.Kamakura M.Nature 473:478-483(2011)

Small volumes of MRJP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1134959 is a recombinant protein targeting MRJP1. Also known as Recombinant Apis mellifera Major royal jelly protein 1 (MRJP1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.