Human PPP1R12B Recombinant Protein – Cat# MBS1135535

Protein Phosphatase 1 Regulatory Subunit 12b (PPP1R12B) Human Recombinant Protein

Name: PPP1R12B Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1135535
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1135535

Myosin light chain phosphatase (MLCP) consists of three subunits- catalytic subunit, large subunitmyosin binding subunit (MBS) and small subunit (sm-M20). This gene is a multi-functional gene which encodes both MBS and sm-M20. MLCP regulates myosins and the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Protein phosphatase 1 regulatory subunit 12B (PPP1R12B), Recombinant Protein

Full Product Name

Recombinant Human Protein phosphatase 1 regulatory subunit 12B (PPP1R12B) , partial

Product Gene Name

PPP1R12B recombinant protein

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

116,504 Da

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

603768

3D Structure

ModBase 3D Structure for O60237

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PPP1R12B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPP1R12B purchase

MBS1135535 is a recombinant protein targeting PPP1R12B. Also known as Recombinant Human Protein phosphatase 1 regulatory subunit 12B (PPP1R12B) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for PPP1R12B. It may not necessarily be applicable to this product.

NCBI GI #

268607512

NCBI GeneID

4660

NCBI Accession #

NP_001161329.1

UniProt Primary Accession #

O60237

UniProt Secondary Accession #

Q2TAI8; Q5T506; Q5VUK2; Q8N179; Q9HCB7; Q9HCB8; A0A0A0MS24; A8MYF5; B7ZMN6

UniProt Related Accession #

O60237

GenBank Nucleotide #

NM_001167857.1

NCBI Official Full Name

protein phosphatase 1 regulatory subunit 12B isoform e

NCBI Official Synonym Full Names

protein phosphatase 1 regulatory subunit 12B

NCBI Official Symbol

PPP1R12B

NCBI Official Synonym Symbols

MYPT2; PP1bp55

UniProt Protein Name

Protein phosphatase 1 regulatory subunit 12B

UniProt Synonym Protein Names

Myosin phosphatase-targeting subunit 2; Myosin phosphatase target subunit 2

Protein Family

Protein phosphatase 1 regulatory

UniProt Gene Name

PPP1R12B

UniProt Synonym Gene Names

MYPT2; Myosin phosphatase target subunit 2

NCBI Protein Information

protein phosphatase 1 regulatory subunit 12B

NCBI Summary for PPP1R12B

Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]

UniProt Comments for PPP1R12B

Regulates myosin phosphatase activity. Augments Ca2+ sensitivity of the contractile apparatus.

Research Articles on PPP1R12B

1. PPP1R12B is associated with childhood asthma in a Russian population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PPP1R12B recombinant protein

Reference Product	PubMed Publications
PPP1R14A recombinant protein	>1 publications with PPP1R12B and PPP1R14A

Pathways associated with PPP1R12B recombinant protein

Products by Pathway	Pathway Diagram
Vascular Smooth Muscle Contraction Pathway antibodies	Vascular Smooth Muscle Contraction Pathway Diagram
Vascular Smooth Muscle Contraction Pathway antibodies	Vascular Smooth Muscle Contraction Pathway Diagram

Diseases associated with PPP1R12B recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1 publications with PPP1R12B and Neoplasms

Organs/Tissues associated with PPP1R12B recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>1 publications with PPP1R12B and Lung