Human MASP2 Recombinant Protein – Cat# MBS1139577

Mannan-Binding Lectin Serine Protease 2 (MASP2) Human Recombinant Protein

Name: MASP2 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1139577
Price: 340 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1139577

The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that… More details

$340 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Mannan-binding lectin serine protease 2 (MASP2), Recombinant Protein

Full Product Name

Recombinant Human Mannan-binding lectin serine protease 2 (MASP2)

Product Gene Name

MASP2 recombinant protein

Sequence

TPLGPKWPEP VFGRLASPGF PGEYANDQER RWTLTAPPGY RLRLYFTHFD LELSHLCEYD FVKLSSGAKV LATLCGQEST DTERAPGKDT FYSLGSSLDI TFRSDYSNEK PFTGFEAFYA AEDIDECQVA PGEAPTCDHH CHNHLGGFYC SCRAGYVLHR NKRTCSALCS GQVFTQRSGE LSSPEYPRPY PKLSSCTYSI SLEEGFSVIL DFVESFDVET HPETLCPYDF LKIQTDREEH GPFCGKTLPH RIETKSNTVT ITFVTDESGD HTGWKIHYTS TAQPCPYPMA PPNGHVSPVQ AKYILKDSFS IFCETGYELL QGHLPLKSFT AVCQKDGSWD RPMPACSIVD CGPPDDLPSG RVEYITGPGV TTYKAVIQYS CEETFYTMKV NDGKYVCEAD GFWTSSKGEK SLPVCEPVCG LSARTTGGRI YGGQKAKPGD FPWQVLILGG TTAAGALLYD NWVLTAAHAV YEQKHDASAL DIRMGTLKRL SPHYTQAWSE AVFIHEGYTH DAGFDNDIAL IKLNNKVVIN SNITPICLPR KEAESFMRTD DIGTASGWGL TQRGFLARNL MYVDIPIVDH QKCTAAYEKP PYPRGSVTAN MLCAGLESGG KDSCRGDSGG ALVFLDSETE RWFVGGIVSW GSMNCGEAGQ YGVYTKVINY IPWIENIISD F

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

20,629 Da

Sequence Positions

16-686aa; Full Length of Mature Protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

605102

3D Structure

ModBase 3D Structure for O00187

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MASP2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MASP2 purchase

MBS1139577 is a recombinant protein targeting MASP2. Also known as Recombinant Human Mannan-binding lectin serine protease 2 (MASP2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for MASP2. It may not necessarily be applicable to this product.

NCBI GI #

21264363

NCBI GeneID

10747

NCBI Accession #

NP_006601.2

UniProt Primary Accession #

O00187

UniProt Secondary Accession #

O75754; Q5TEQ5; Q5TER0; Q96QG4; Q9BZH0; Q9H498; Q9H499; Q9UBP3; Q9UC48; A8K458; A8MWJ2

UniProt Related Accession #

O00187

GenBank Nucleotide #

NM_006610.3

NCBI Official Full Name

mannan-binding lectin serine protease 2 isoform 1 preproprotein

NCBI Official Synonym Full Names

mannan binding lectin serine peptidase 2

NCBI Official Symbol

MASP2

NCBI Official Synonym Symbols

sMAP; MAP19; MASP-2; MASP1P1

UniProt Protein Name

Mannan-binding lectin serine protease 2

UniProt Synonym Protein Names

MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2

Protein Family

Mannan-binding lectin serine protease

UniProt Gene Name

MASP2

UniProt Synonym Gene Names

MASP-2

NCBI Protein Information

mannan-binding lectin serine protease 2

NCBI Summary for MASP2

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

UniProt Comments for MASP2

Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.

Research Articles on MASP2

1. The complement lectin pathway serine proteases, MASP-1 and MASP-2, can be associated with ischaemic stroke development risk and may participate in pathological events leading to post-ischaemic brain damage. Moreover rs3203210 and rs147270785 single nucleotide polymorphisms in the MASP1 and MASP2 genes, respectively, are strongly associated with ischaemic stroke.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MASP2 recombinant protein

Reference Product	PubMed Publications
MBL2 recombinant protein	>31 publications with MASP2 and MBL2
SERPING1 recombinant protein	>4 publications with MASP2 and SERPING1
FCN2 recombinant protein	>4 publications with MASP2 and FCN2

Pathways associated with MASP2 recombinant protein

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Creation Of C4 And C2 Activators Pathway antibodies	Creation Of C4 And C2 Activators Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Initial Triggering Of Complement Pathway antibodies	Initial Triggering Of Complement Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Lectin Pathway Of Complement Activation antibodies	Lectin Pathway Of Complement Activation Diagram
Staphylococcus Aureus Infection Pathway antibodies	Staphylococcus Aureus Infection Pathway Diagram

Diseases associated with MASP2 recombinant protein

Disease Name	Pubmed Publications
MASP2 Deficiency Antibodies	>40 publications with MASP2 and MASP2 Deficiency
Inflammation Antibodies	>23 publications with MASP2 and Inflammation
Liver Diseases Antibodies	>6 publications with MASP2 and Liver Diseases
Kidney Diseases Antibodies	>5 publications with MASP2 and Kidney Diseases
Hepatitis Antibodies	>5 publications with MASP2 and Hepatitis
Fibrosis Antibodies	>5 publications with MASP2 and Fibrosis
Brain Diseases Antibodies	>4 publications with MASP2 and Brain Diseases
Nephritis Antibodies	>3 publications with MASP2 and Nephritis
Disease Models, Animal Antibodies	>3 publications with MASP2 and Disease Models, Animal
Carcinoma, Hepatocellular Antibodies	>2 publications with MASP2 and Carcinoma, Hepatocellular

Organs/Tissues associated with MASP2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>17 publications with MASP2 and Liver
Lung Antibodies	>8 publications with MASP2 and Lung
Brain Antibodies	>6 publications with MASP2 and Brain
Placenta Antibodies	>1 publications with MASP2 and Placenta
Thyroid Antibodies	>1 publications with MASP2 and Thyroid
Embryonic Tissue Antibodies	>1 publications with MASP2 and Embryonic Tissue