Human LAMA5 Recombinant Protein – Cat# MBS1145831

Laminin Subunit Alpha-5 (LAMA5) Human Recombinant Protein

Name: LAMA5 Recombinant Protein; Laminin Subunit Alpha-5; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1145831
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1145831

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during emembryonic development by interacting with other extracellular matrix components. More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Laminin subunit alpha-5 (LAMA5), Recombinant Protein

Full Product Name

Recombinant Human Laminin subunit alpha-5 (LAMA5), partial

Product Gene Name

LAMA5 recombinant protein

Product Synonym Names

Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha

Sequence

FVAQMEGLGT RLRAQSRQRS RPGRWHKVSV RWEKNRILLV TDGARAWSQE GPHRQHQGAE HPQPHTLFVG GLPASSHSSK LPVTVGFSGC VKRLRLHGRP LGAPTRMAGV TPCILGPLEA GLFFPGSGGV ITLDLPGATL PDVGLELEVR PLAVTGLIFH LGQARTPPYL QLQVTEKQVL LRADDGAGEF STSVTRPSVL CDGQWHRLAV MKSGNVLRLE VDAQSNHTVG PLLAAAAGAP APLYLGGLPE PMAVQPWPPA YCGCMRRLAV NRSPVAMTRS VEVHGAVGAS GC

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

47.1 kDa

Sequence Positions

3401-3692. Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

601033

3D Structure

ModBase 3D Structure for O15230

Species

Homo sapiens (Human)

Production Note

Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for LAMA5 recombinant protein

Neuroscience

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for LAMA5 recombinant protein

"Recombinant human laminin-10 (alpha5beta1gamma1). Production, purification, and migration-promoting activity on vascular endothelial cells." Doi M., Thyboll J., Kortesmaa J., Jansson K., Iivanainen A., Parvardeh M., Timpl R., Hedin U., Swedenborg J., Tryggvason K. J. Biol. Chem. 277:12741-12748(2002)

Other Notes

Small volumes of LAMA5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LAMA5 purchase

MBS1145831 is a recombinant protein targeting LAMA5. Also known as Recombinant Human Laminin subunit alpha-5 (LAMA5), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for LAMA5. It may not necessarily be applicable to this product.

NCBI GI #

21264602

NCBI GeneID

3911

NCBI Accession #

NP_005551.3

UniProt Primary Accession #

O15230

UniProt Secondary Accession #

Q5U4N9; Q8TDF8; Q8WZA7; Q9H1P1

UniProt Related Accession #

O15230

GenBank Nucleotide #

NM_005560.4

NCBI Official Full Name

laminin subunit alpha-5

NCBI Official Synonym Full Names

laminin subunit alpha 5

NCBI Official Symbol

LAMA5

UniProt Protein Name

Laminin subunit alpha-5

UniProt Synonym Protein Names

Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha

Protein Family

Laminin

UniProt Gene Name

LAMA5

UniProt Synonym Gene Names

KIAA0533; KIAA1907

UniProt Entry Name

LAMA5_HUMAN

NCBI Protein Information

laminin subunit alpha-5

NCBI Summary for LAMA5

This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]

UniProt Comments for LAMA5

LAMA5: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: 20q13.2-q13.3

Cellular Component: basal lamina; basement membrane; extracellular matrix; extracellular region; extracellular space; laminin-10 complex; laminin-5 complex; nucleus

Molecular Function: integrin binding; structural molecule activity

Biological Process: angiogenesis; cell differentiation; cell migration; cell proliferation; cell recognition; cilium biogenesis; cytoskeleton organization and biogenesis; embryonic development; endothelial cell differentiation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; focal adhesion formation; hair follicle development; integrin-mediated signaling pathway; lung development; morphogenesis of a polarized epithelium; morphogenesis of embryonic epithelium; muscle development; neural crest cell migration; odontogenesis of dentine-containing teeth; regulation of cell adhesion; regulation of cell migration; regulation of cell proliferation; regulation of embryonic development; ureteric bud branching

Research Articles on LAMA5

1. Gal-1 decreased the expression of collagen genes COL3A1 and COL5A1 but increased the expression of fibronectin and laminin 5.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LAMA5 recombinant protein

Reference Product	PubMed Publications
LAMA1 recombinant protein	>4 publications with LAMA5 and LAMA1
LAMB2 recombinant protein	>4 publications with LAMA5 and LAMB2
ITGB4 recombinant protein	>3 publications with LAMA5 and ITGB4
ITGA3 recombinant protein	>2 publications with LAMA5 and ITGA3
LAMB1 recombinant protein	>2 publications with LAMA5 and LAMB1
LAMB3 recombinant protein	>1 publications with LAMA5 and LAMB3
ITGB1 recombinant protein	>1 publications with LAMA5 and ITGB1
ITGA6 recombinant protein	>1 publications with LAMA5 and ITGA6
LAMC1 recombinant protein	>1 publications with LAMA5 and LAMC1

Pathways associated with LAMA5 recombinant protein

Products by Pathway	Pathway Diagram
Alpha6-Beta4 Integrin Signaling Pathway antibodies	Alpha6-Beta4 Integrin Signaling Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
ECM Proteoglycans Pathway antibodies	ECM Proteoglycans Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram

Diseases associated with LAMA5 recombinant protein

Disease Name	Pubmed Publications
Kidney Diseases Antibodies	>5 publications with LAMA5 and Kidney Diseases
Congenital Abnormalities Antibodies	>4 publications with LAMA5 and Congenital Abnormalities
Disease Models, Animal Antibodies	>3 publications with LAMA5 and Disease Models, Animal
Carcinoma Antibodies	>3 publications with LAMA5 and Carcinoma
Breast Neoplasms Antibodies	>2 publications with LAMA5 and Breast Neoplasms
Lung Diseases Antibodies	>2 publications with LAMA5 and Lung Diseases
Inflammation Antibodies	>2 publications with LAMA5 and Inflammation
Fibrosis Antibodies	>1 publications with LAMA5 and Fibrosis
Cardiovascular Diseases Antibodies	>1 publications with LAMA5 and Cardiovascular Diseases
Cell Transformation, Neoplastic Antibodies	>1 publications with LAMA5 and Cell Transformation, Neoplastic

Organs/Tissues associated with LAMA5 recombinant protein

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>10 publications with LAMA5 and Kidney
Embryonic Tissue Antibodies	>10 publications with LAMA5 and Embryonic Tissue
Lung Antibodies	>7 publications with LAMA5 and Lung
Vascular Antibodies	>7 publications with LAMA5 and Vascular
Skin Antibodies	>5 publications with LAMA5 and Skin
Placenta Antibodies	>4 publications with LAMA5 and Placenta
Liver Antibodies	>3 publications with LAMA5 and Liver
Mouth Antibodies	>2 publications with LAMA5 and Mouth
Heart Antibodies	>2 publications with LAMA5 and Heart
Spleen Antibodies	>1 publications with LAMA5 and Spleen