Trans-Activator Protein BZLF1 (BZLF1) Epstein-Barr Virus Recombinant Protein

Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1).

DNA sequence and expression of the B95-8 Epstein-Barr virus genome.Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J., Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C., Tuffnell P.S., Barrell B.G.Nature 310:207-211(1984) Epstein-Barr virus gene expression in P3HR1-superinfected Raji cells.Biggin M., Bodescot M., Perricaudet M., Farrel P.J. Virol. 61:3120-3132(1987) Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos.Farrel P.J., Rowe D.T., Rooney C.M., Kouzarides T.EMBO J. 8:127-132(1989) Structure and function of the Epstein-Barr virus BZLF1 protein.Packham G., Economou A., Rooney C.M., Rowe D.T., Farrel P.J.J. Virol. 64:2110-2116(1990) The BZLF1 protein of EBV has a coiled coil dimerisation domain without a heptad leucine repeat but with homology to the C/EBP leucine zipper.Kouzarides T., Packham G., Cook A., Farrell P.J.Oncogene 6:195-204(1991) A transcription factor with homology to the AP-1 family links RNA transcription and DNA replication in the lytic cycle of Epstein-Barr virus.Schepers A., Pich D., Hammerschmidt W.EMBO J. 12:3921-3929(1993) The PKC targeting protein RACK1 interacts with the Epstein-Barr virus activator protein BZLF1.Baumann M., Gires O., Kolch W., Mischak H., Zeidler R., Pich D., Hammerschmidt W.Eur. J. Biochem. 267:3891-3901(2000) Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors.Aho S., Buisson M., Pajunen T., Ryoo Y.W., Giot J.-F., Gruffat H., Sergeant A., Uitto J.J. Cell Biol. 148:1165-1176(2000) Epstein-Barr virus BZLF1 gene, a switch from latency to lytic infection, is expressed as an immediate-early gene after primary infection of B lymphocytes.Wen W., Iwakiri D., Yamamoto K., Maruo S., Kanda T., Takada K.J. Virol. 81:1037-1042(2007) TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein.Murata T., Sato Y., Nakayama S., Kudoh A., Iwahori S., Isomura H., Tajima M., Hishiki T., Ohshima T., Hijikata M., Shimotohno K., Tsurumi T.J. Biol. Chem. 284:8033-8041(2009) Interaction of Epstein-Barr virus BZLF1 C-terminal tail structure and core zipper is required for DNA replication but not for promoter transactivation.McDonald C.M., Petosa C., Farrell P.J.J. Virol. 83:3397-3401(2009) Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein.Petosa C., Morand P., Baudin F., Moulin M., Artero J.B., Muller C.W.Mol. Cell 21:565-572(2006)

Small volumes of BZLF1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1146552 is a recombinant protein targeting BZLF1. Also known as Recombinant Epstein-Barr virus Trans-activator protein BZLF1 (BZLF1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.