5-Hydroxytryptamine Receptor 3b (HTR3B) Human Recombinant Protein

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]

5-HT(3B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation; Channel, ligand-gated; Transporter, ion channel

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane

Molecular Function: serotonin-activated cation-selective channel activity; serotonin receptor activity; ion channel activity

Biological Process: synaptic transmission; transport; transmembrane transport; serotonin receptor signaling pathway