Rat CMKLR1 Recombinant Protein – Cat# MBS1152874

Chemokine-Like Receptor 1 (CMKLR1) Rat Recombinant Protein

Name: CMKLR1 Recombinant Protein; Chemokine-Like Receptor 1; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS1152874
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1152874

MBS1152874 is a recombinant protein targeting Cmklr1. Also known as Recombinant Rat Chemokine-like receptor 1 (Cmklr1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Chemokine-like receptor 1 (Cmklr1), Recombinant Protein

Full Product Name

Recombinant Rat Chemokine-like receptor 1 (Cmklr1)

Product Gene Name

Cmklr1 recombinant protein

Product Synonym Gene Name

Cmklr1; Dez

Product Synonym Names

Recombinant Chemokine-like receptor 1 (Cmklr1); Chemokine-like receptor 1; G-protein coupled chemoattractant-like receptor G-protein coupled receptor DEZ

Sequence

MEYEGYNDSS IYGEEYSDGS DYIVDLEEAG PLEAKVAEVF LVVIYSLVCF LGILGNGLVI VIATFKMKKT VNTVWFVNLA VADFLFNIFL PIHITYAAMD YHWVFGKAMC KISSFLLSHN MYTSVFLLTV ISFDRCISVL LPVWSQNHRS VRLAYMTCVV VWVWLSSESP PSLVFGHVST SHGKITCFNN FSLAAPEPFS HSTHPRTDPV GYSRHVAVTV TRFLCGFLIP VFIITACYLT IVFKLQRNRQ AKTKKPFKII ITIIITFFLC WCPYHTLYLL ELHHTAVPAS VFSLGLPLAT AVAIANSCMN PILYVFMGHD FKKFKVALFS RLVNALSEDT GPSSYPSHRS FTKMSSLIEK ASVNEKETST L

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

41,723 Da

Sequence Positions

1-371

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 12; NC_005111.3 (50577124..50581377). Location: 12q16

3D Structure

ModBase 3D Structure for O35786

Species

Rattus norvegicus (Rat)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cmklr1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Cmklr1. It may not necessarily be applicable to this product.

NCBI GI #

3023640

NCBI GeneID

60669

NCBI Accession #

O35786.1

UniProt Primary Accession #

O35786

UniProt Related Accession #

O35786

NCBI Official Full Name

Chemokine-like receptor 1

NCBI Official Synonym Full Names

chemokine-like receptor 1

NCBI Official Symbol

Cmklr1

UniProt Protein Name

Chemokine-like receptor 1

UniProt Synonym Protein Names

G-protein coupled chemoattractant-like receptor; G-protein coupled receptor DEZ

UniProt Gene Name

Cmklr1

UniProt Synonym Gene Names

Dez

UniProt Entry Name

CML1_RAT

NCBI Protein Information

chemokine-like receptor 1; chemokine receptor-like 1; G-protein coupled receptor DEZ; G-protein coupled chemoattractant-like receptor

NCBI Summary for Cmklr1

may be a member of the chemokine receptor family [RGD, Feb 2006]

UniProt Comments for Cmklr1

CMKLR1: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Cellular Component: integral to membrane; plasma membrane

Molecular Function: G-protein chemoattractant receptor activity; chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of interleukin-12 production; inhibition of NF-kappaB transcription factor; positive regulation of fat cell differentiation; regulation of calcium-mediated signaling; chemotaxis

Research Articles on Cmklr1

1. Changed expression of brain CMKLR1 is suggested to be involved in the mechanism of depression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Cmklr1 recombinant protein

Products by Pathway	Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram

Organs/Tissues associated with Cmklr1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>11 publications with Cmklr1 and Lung
Connective Tissue Antibodies	>9 publications with Cmklr1 and Connective Tissue
Heart Antibodies	>6 publications with Cmklr1 and Heart
Artery Antibodies	>3 publications with Cmklr1 and Artery
Kidney Antibodies	>2 publications with Cmklr1 and Kidney