Tumor Necrosis Factor Ligand Superfamily Member 11 (TNFSF11) Mouse Recombinant Protein

TNFSF11: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Homotrimer. Up-regulated by T-cell receptor stimulation. Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: cytoplasm; extracellular region; extracellular space; integral to membrane; membrane; plasma membrane

Molecular Function: cytokine activity; protein binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: activation of JNK activity; activation of NF-kappaB transcription factor; bone resorption; calcium ion homeostasis; cell differentiation; cytokine and chemokine mediated signaling pathway; immune response; lymph node development; mammary gland epithelial cell proliferation; monocyte chemotaxis; multicellular organismal development; organ morphogenesis; ossification; osteoclast differentiation; positive regulation of bone resorption; positive regulation of corticotropin-releasing hormone secretion; positive regulation of homotypic cell-cell adhesion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of osteoclast differentiation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of T cell activation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein homooligomerization; regulation of osteoclast differentiation; tumor necrosis factor-mediated signaling pathway