Guanine Nucleotide-Binding Protein G (O) Subunit Alpha (goa-1) Caenorhabditis Elegans Recombinant Protein

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. In the 1-cell embryo, probably together with gpa-16, controls nuclear rotation and spindle elongation during mitosis (PubMed:14534135). During the first embryonic cell divisions, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle (PubMed:14534135). Polarity determinants (par genes) may regulate lin-5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement (PubMed:12730122). Involved in chemosensory responses to attractive and repellent odors detected by AWC and AWB sensory neurons, respectively (PubMed:23954825). Negatively regulates axon regeneration after injury downstream of the inhibitory compound arachidonoyl ethanolamide (AEA) by antagonizing the activation of the JNK pathway (mlk-1/mek-1/kgb-1) (PubMed:23072806). In neurons, may negatively regulate diacylglycerol (DAG) production mediated by egl-30 signaling cascade and thereby negatively regulates acetylcholine release (PubMed:22897658). Couples to the muscarinic acetylcholine receptor gar-2 to negatively regulate cholinergic receptor activity in the presence of high levels of acetylcholine in ventral cord motor neurons (PubMed:18614679). Involved in egg-laying and locomotion (PubMed:8548815).