Minor Capsid Protein VP2 Murine Polyomavirus Recombinant Protein

Function: Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2 or Vp3 nuclear localization signal (shared C-terminus). Plays a role in virion assembly within the nucleus in particular through a DNA-binding domain located in the C-terminal region. A N-terminal myristoylation suggests a scaffold function for virion assembly

By similarity.Isoform VP3: structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2 or Vp3 nuclear localization signal (shared C-terminus). Isoform VP3 plays a role in virion assembly within the nucleus

By similarity.

Subunit structure: Isoform VP2 forms homooligomers, and heterooligomers with VP3 in the endoplasmic reticulum membrane. Isoform VP2 interacts (via D1 domain) with VP1. Isoform VP3 interacts (via D1 domain) with VP1

By similarity.

Subcellular location: Isoform VP2: Virion. Host nucleus. Host endoplasmic reticulum. Host endoplasmic reticulum membrane

By similarity. Isoform VP3: Virion. Host nucleus. Host endoplasmic reticulum. Host endoplasmic reticulum membrane

By similarity.

Sequence similarities: Belongs to the polyomaviruses capsid protein VP2 family.