Human NRG2 Recombinant Protein – Cat# MBS1164697

Pro-Neuregulin-2 (NRG2) Human Recombinant Protein

Name: NRG2 Recombinant Protein; Pro-Neuregulin-2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1164697
Price: 575 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1164697

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF… More details

$575 / 0.02 mg (Baculovirus) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Pro-neuregulin-2 (NRG2), Recombinant Protein

Full Product Name

Recombinant Human Pro-neuregulin-2, membrane-bound isoform

Product Gene Name

NRG2 recombinant protein

Product Synonym Names

Divergent of neuregulin-1; DON-1; Neural- and thymus-derived activator for ERBB kinases; NTAK

Sequence

CYSPSLKSVQ DQAYKAPVVV EGKVQGLVPA GGSSSNSTRE PPASGRVALV KVLDKWPLRS GGLQREQVIS VGSCVPLERN QRYIFFLEPT EQPLVFKTAF APLDTNGKNL KKEVGKILCT DCATRPKLKK MKSQTGQVGE KQSLKCEAAA GNPQPSYRWF KDGKELNRSR DIRIKYGNGR KNSRLQFNKV KVEDAGEYVC EAENILGKDT VRGRLYVNSV STTLSSWSGH ARKCNETAKS YCVNGGVCYY IEGINQLSCK CPNGFFGQRC LEKLPLRLYM PDPKQKAEEL YQKR

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

34.8 kDa

Sequence Positions

112-405. Partial, provide the Extracellular Domain

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

603818

3D Structure

ModBase 3D Structure for O14511

Product Categories/Family for NRG2 recombinant protein

Neuroscience

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for NRG2 recombinant protein

A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4.Higashiyama S., Horikawa M., Yamada K., Ichino N., Nakano N., Nakagawa T., Miyagawa J., Matsushita N., Nagatsu T., Taniguchi N., Ishiguro H.J. Biochem. 122:675-680(1997) Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus.Busfield S.J., Michnick D.A., Chickering T.W., Revett T.L., Ma J., Woolf E.A., Comrack C.A., Dussault B.J., Woolf J., Goodearl A.D.J., Gearing D.P.Mol. Cell. Biol. 17:4007-4014(1997) The human neuregulin 2 (NRG2) gene cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q.Ring H.Z., Chang H., Guilbot A., Brice A., LeGuern E., Francke U.Hum. Genet. 104:326-332(1999) Ligand discrimination in signaling through an ErbB4 receptor homodimer.Sweeney C., Lai C., Riese D.J. II, Diamonti A.J., Cantley L.C., Carraway K.L. IIIJ. Biol. Chem. 275:19803-19807(2000)

Other Notes

Small volumes of NRG2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NRG2 purchase

MBS1164697 is a recombinant protein targeting NRG2. Also known as Recombinant Human Pro-neuregulin-2, membrane-bound isoform. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for NRG2. It may not necessarily be applicable to this product.

NCBI GI #

296531452

NCBI GeneID

9542

NCBI Accession #

NP_001171864.1

UniProt Primary Accession #

O14511

UniProt Related Accession #

O14511

GenBank Nucleotide #

NM_001184935.1

NCBI Official Full Name

pro-neuregulin-2, membrane-bound isoform isoform 7

NCBI Official Synonym Full Names

neuregulin 2

NCBI Official Symbol

NRG2

NCBI Official Synonym Symbols

DON1; HRG2; NTAK

UniProt Protein Name

Pro-neuregulin-2, membrane-bound isoform

UniProt Synonym Protein Names

Neuregulin-2; NRG-2

Protein Family

Pro-neuregulin

UniProt Gene Name

NRG2

UniProt Synonym Gene Names

NTAK; Pro-NRG2; NRG-2; DON-1; NTAK

UniProt Entry Name

NRG2_HUMAN

NCBI Protein Information

pro-neuregulin-2, membrane-bound isoform

NCBI Summary for NRG2

This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]

UniProt Comments for NRG2

NRG2: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. Belongs to the neuregulin family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: extracellular region; extracellular space; integral to membrane; intracellular; plasma membrane

Molecular Function: growth factor activity; receptor binding

Biological Process: activation of MAPKK activity; axon guidance; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; organ development; phosphoinositide-mediated signaling; Ras protein signal transduction; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway

Research Articles on NRG2

1. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NRG2 recombinant protein

Reference Product	PubMed Publications
NRG1 recombinant protein	>37 publications with NRG2 and NRG1
ERBB4 recombinant protein	>30 publications with NRG2 and ERBB4
ERBB2 recombinant protein	>27 publications with NRG2 and ERBB2
ERBB3 recombinant protein	>19 publications with NRG2 and ERBB3
NRG3 recombinant protein	>17 publications with NRG2 and NRG3
EGFR recombinant protein	>12 publications with NRG2 and EGFR
NRG4 recombinant protein	>8 publications with NRG2 and NRG4
HBEGF recombinant protein	>6 publications with NRG2 and HBEGF
EREG recombinant protein	>5 publications with NRG2 and EREG
ADAM17 recombinant protein	>1 publications with NRG2 and ADAM17

Pathways associated with NRG2 recombinant protein

Products by Pathway	Pathway Diagram
ARMS-mediated Activation Pathway antibodies	ARMS-mediated Activation Pathway Diagram
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Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies	Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Diseases Of Signal Transduction Pathway antibodies	Diseases Of Signal Transduction Pathway Diagram

Diseases associated with NRG2 recombinant protein

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>9 publications with NRG2 and Breast Neoplasms
Nervous System Diseases Antibodies	>5 publications with NRG2 and Nervous System Diseases
Heart Diseases Antibodies	>3 publications with NRG2 and Heart Diseases
Brain Diseases Antibodies	>2 publications with NRG2 and Brain Diseases
Chromosome Aberrations Antibodies	>2 publications with NRG2 and Chromosome Aberrations
Lung Diseases Antibodies	>2 publications with NRG2 and Lung Diseases
Inflammation Antibodies	>2 publications with NRG2 and Inflammation
Liver Neoplasms Antibodies	>1 publications with NRG2 and Liver Neoplasms
Respiratory Tract Diseases Antibodies	>1 publications with NRG2 and Respiratory Tract Diseases
Precancerous Conditions Antibodies	>1 publications with NRG2 and Precancerous Conditions

Organs/Tissues associated with NRG2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>17 publications with NRG2 and Brain
Thymus Antibodies	>4 publications with NRG2 and Thymus
Lung Antibodies	>3 publications with NRG2 and Lung
Skin Antibodies	>1 publications with NRG2 and Skin
Prostate Antibodies	>1 publications with NRG2 and Prostate
Pancreas Antibodies	>1 publications with NRG2 and Pancreas