B-Cell Lymphoma/Leukemia 10 (BCL10) Human Recombinant Protein

Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.

Bcl10 is involved in t(1;14) (p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.Willis T.G., Jadayel D.M., Du M.-Q., Peng H., Perry A.R., Abdul-Rauf M., Price H., Karran L., Majekodunmi O., Wlodarska I., Pan L., Crook T., Hamoudi R., Isaacson P., Dyer M.J.S.Cell 96:35-45(1999) CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10.Koseki T., Inohara N., Chen S., Carrio R., Merino J., Hottiger M.O., Nabel G.J., Nunez G.J. Biol. Chem. 274:9955-9961(1999) Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase.Thome M., Martinon F., Hofmann K., Rubio V., Steiner V., Schneider P., Mattmann C., Tschopp J.J. Biol. Chem. 274:9962-9968(1999) mE10, a novel caspase recruitment domain-containing proapoptotic molecule.Yan M., Lee J., Schilbach S., Goddard A., Dixit V.M.J. Biol. Chem. 274:10287-10292(1999) CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis.Srinivasula S.M., Ahmad M., Lin J.-H., Poyet J.-L., Fernandes-Alnemri T., Tsichlis P.N., Alnemri E.S.J. Biol. Chem. 274:17946-17954(1999) c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB.Costanzo A., Guiet C., Vito P.J. Biol. Chem. 274:20127-20132(1999) Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14) (p22;q32) .Zhang Q., Siebert R., Yan M., Hinzmann B., Cui X., Xue L., Rakestraw K.M., Naeve C.W., Beckmann G., Weisenburger D.D., Sanger W.G., Nowotny H., Vesely M., Callet-Bauchu E., Salles G., Dixit V.M., Rosenthal A., Schlegelberger B., Morris S.W.Nat. 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Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling.Yui D., Yoneda T., Oono K., Katayama T., Imaizumi K., Tohyama M.Oncogene 20:4317-4323(2001) Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.Ohnuma K., Uchiyama M., Yamochi T., Nishibashi K., Hosono O., Takahashi N., Kina S., Tanaka H., Lin X., Dang N.H., Morimoto C.J. Biol. Chem. 282:10117-10131(2007) Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10.Lobry C., Lopez T., Israel A., Weil R.Proc. Natl. Acad. Sci. U.S.A. 104:908-913(2007) The proteolytic activity of the paracaspase MALT1 is key in T cell activation.Rebeaud F., Hailfinger S., Posevitz-Fejfar A., Tapernoux M., Moser R., Rueda D., Gaide O., Guzzardi M., Iancu E.M., Rufer N., Fasel N., Thome M.Nat. Immunol. 9:272-281(2008) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.Anal. Chem. 81:4493-4501(2009) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.Sci. Signal. 4:RS3-RS3(2011) Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity.Torres J.M., Martinez-Barricarte R., Garcia-Gomez S., Mazariegos M.S., Itan Y., Boisson B., Rholvarez R., Jimenez-Reinoso A., Del Pino L., Rodriguez-Pena R., Ferreira A., Hernandez-Jimenez E., Toledano V., Cubillos-Zapata C., Diaz-Almiron M., Lopez-Collazo E., Unzueta-Roch J.L., Sanchez-Ramon S., Regueiro J.R., Lopez-Granados E., Casanova J.L., Perez de Diego R.J. Clin. Invest. 124:5239-5248(2014) Absence of BCL10 mutations in human malignant mesothelioma.Apostolou S., de Rienzo A., Murthy S.S., Jhanwar S.C., Testa J.R.Cell 97:684-686(1999) +Additional computationally mapped references.<p>Provides general information on the entry.

Small volumes of BCL10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1164977 is a recombinant protein targeting BCL10. Also known as Recombinant Human B-cell lymphoma/leukemia 10. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.