• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Integral Membrane Protein 2c (ITM2C) Bovine Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1172769

MBS1172769 is a recombinant protein targeting ITM2C. Also known as Recombinant Bovine Integral membrane protein 2C (ITM2C). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Integral membrane protein 2C (ITM2C), Recombinant Protein
Full Product Name
Recombinant Bovine Integral membrane protein 2C (ITM2C)
Product Gene Name
ITM2C recombinant protein
Product Synonym Gene Name
ITM2C
Product Synonym Names
Recombinant Integral membrane protein 2C (ITM2C); Integral membrane protein 2C Cleaved into the following chain: 1. CT-BRI3
Sequence
MVKISFQPAV AGIKGDKADK ASASASASAP APTPAAEILL TPAREERPPY QRYKKGGSVG GVCYLSMGMV VLLMGLVFAS VYIYRYFFLA QLARDNFFHC GVLYEDSLSS QAHTRMELEE DVKIYLEENY ERINVPVPQF GGGDPADIIH DFQRGLTAYH DISLDKCYVI ELNTTIVLPP RNFWELLMNV KRGTYLPQTY IIQEEMVVTE HVSDKEALGS FIYHLCSGKD TYRLRRRATR RRINKREAKN CNAIRHFENT FVVETLICGV V
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
30,673 Da
Sequence Positions
1-271
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 2; AC_000159.1 (119476496..119490381). Location: chromosome: 2
3D Structure
ModBase 3D Structure for A2VDN0
Species
Bos taurus (Bovine)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ITM2C recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ITM2C. It may not necessarily be applicable to this product.

NCBI GI #
125630709
NCBI GeneID
539959
NCBI Accession #
NP_001075007.1
UniProt Primary Accession #
A2VDN0
UniProt Related Accession #
A2VDN0
GenBank Nucleotide #
NM_001081538.1
NCBI Official Full Name
integral membrane protein 2C
NCBI Official Synonym Full Names
integral membrane protein 2C<
NCBI Official Symbol
ITM2C
NCBI Official Synonym Symbols
ITM3
UniProt Protein Name
Integral membrane protein 2C
Protein Family
Integral membrane protein
UniProt Gene Name
ITM2C
UniProt Entry Name
ITM2C_BOVIN
NCBI Protein Information
integral membrane protein 2C; integral membrane protein 3

UniProt Comments for ITM2C

Function: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation

By similarity.

Subunit structure: Interacts with BACE1. Interacts with APP. Interacts with STMN2

By similarity.

Subcellular location: Lysosome membrane; Single-pass type II membrane protein

By similarity. Cell membrane; Single-pass type II membrane protein

By similarity.

Post-translational modification: Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembanaire cleavage by SPPL2B

By similarity.

Sequence similarities: Belongs to the ITM2 family.Contains 1 BRICHOS domain.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with ITM2C recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with ITM2C and Nervous System Diseases
 Myocardial Infarction Antibodies  >1 publications with ITM2C and Myocardial Infarction
 Cardiovascular Diseases Antibodies  >1 publications with ITM2C and Cardiovascular Diseases
 Brain Diseases Antibodies  >1 publications with ITM2C and Brain Diseases
 Cerebral Infarction Antibodies  >1 publications with ITM2C and Cerebral Infarction
 Neoplasms Antibodies  >1 publications with ITM2C and Neoplasms
 Stroke Antibodies  >1 publications with ITM2C and Stroke

Organs/Tissues associated with ITM2C recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with ITM2C and Brain
 Kidney Antibodies  >1 publications with ITM2C and Kidney
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000