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Hemopexin (HPX) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1178366

Binds he and transports it to the liver for breakdown and iron recovery, after which the free hopexin returns to the circulation. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Hemopexin (Hpx), Recombinant Protein
Full Product Name
Recombinant Rat Hemopexin
Product Gene Name
Hpx recombinant protein
Sequence
NPLPAAHETV AKGENGTKPD SDVIEHCSDA WSFDATTMDH NGTMLFFKGE FVWRGHSGIR ELISERWKNP VTSVDAAFRG PDSVFLIKED KVWVYPPEKK ENGYPKLFQE EFPGIPYPPD AAVECHRGEC QSEGVLFFQG NRKWFWDFAT RTQKERSWPA VGNCTAALRW LERYYCFQGN KFLRFNPVTG EVPPRYPLDA RDYFISCPGR GHGKLRNGTA HGNSTHPMHS RCNADPGLSA LLSDHRGATY AFSGSHYWRL DSSRDGWHSW PIAHHWPQGP SAVDAAFSWD EKVYLIQGTQ VYVFLTKGGN NLVSGYPKRL EKELGSPPGI SLDTIDAAFS CPGSSKLYVT SGRRLWWLDL KSGAQATWAE LSWPHEKVDG ALCLEKSLGP YSCSSNGPNL FFIHGPNLYC YSSIDKLNAA KSLPQPQKVN SILGCSQ
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
50.9 kDa
Sequence Positions
24-460aa; Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P20059
Production Note
Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of Hpx recombinant protein

Rat HPX Recombinant Protein – Cat# MBS1178366

Product References and Citations for Hpx recombinant protein

Rat hemopexin. Molecular cloning, primary structural characterization, and analysis of gene expression.Nikkilae H., Gitlin J.D., Mueller-Eberhard U.Biochemistry 30:823-829(1991) Identification of an interleukin-6 responsive element and characterization of the proximal promoter region of the rat hemopexin gene.Nagae Y., Mueller-Eberhard U.Biochem. Biophys. Res. Commun. 185:420-429(1992) N-terminal amino acid sequences of the hemopexins from chicken, rat and rabbit.Wellner D., Cheng K.C., Mueller-Eberhard U.Biochem. Biophys. Res. Commun. 155:622-625(1988) Hemopexin is synthesized in peripheral nerves but not in central nervous system and accumulates after axotomy.Swerts J.P., Soula C., Sagot Y., Guinaudy M.J., Guillemot J.-C., Ferrara P., Duprat A.-M., Cochard P.J. Biol. Chem. 267:10596-10600(1992) Lubec G., Afjehi-Sadat L.Submitted (NOV-2006) to UniProtKB

Other Notes

Small volumes of Hpx recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hpx purchase

MBS1178366 is a recombinant protein targeting Hpx. Also known as Recombinant Rat Hemopexin. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Hpx. It may not necessarily be applicable to this product.

NCBI GI #
16758014
NCBI GeneID
58917
NCBI Accession #
NP_445770.1
UniProt Primary Accession #
P20059
UniProt Secondary Accession #
Q5BKB4
UniProt Related Accession #
P20059
GenBank Nucleotide #
NM_053318.1
NCBI Official Full Name
hemopexin
NCBI Official Synonym Full Names
hemopexin
NCBI Official Symbol
Hpx
NCBI Official Synonym Symbols
Hpxn
UniProt Protein Name
Hemopexin
Protein Family
Hemopexin
UniProt Gene Name
Hpx
UniProt Entry Name
HEMO_RAT
NCBI Protein Information
hemopexin

NCBI Summary for Hpx

a heme binding globulin protein [RGD, Feb 2006]

UniProt Comments for Hpx

HPX: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. Belongs to the hemopexin family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: cell; extracellular space

Molecular Function: heme transporter activity; metal ion binding

Biological Process: cellular iron ion homeostasis; heme metabolic process; heme transport; hemoglobin metabolic process; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of immunoglobulin production; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of protein metabolic process
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Research Articles on Hpx

1. Hemopexin was identified as upregulated protein in the small intestine exposed to indomethacin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Hpx recombinant protein

 Reference Product  PubMed Publications
 Alb recombinant protein  >3 publications with Hpx and Alb
 Fga recombinant protein  >1 publications with Hpx and Fga

Pathways associated with Hpx recombinant protein

 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram

Diseases associated with Hpx recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >22 publications with Hpx and Inflammation
 Liver Diseases Antibodies  >18 publications with Hpx and Liver Diseases
 Nervous System Diseases Antibodies  >13 publications with Hpx and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >8 publications with Hpx and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >8 publications with Hpx and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >7 publications with Hpx and Cardiovascular Diseases
 Death Antibodies  >6 publications with Hpx and Death
 Neoplasms, Experimental Antibodies  >5 publications with Hpx and Neoplasms, Experimental
 Hemolysis Antibodies  >5 publications with Hpx and Hemolysis
 Lung Diseases Antibodies  >5 publications with Hpx and Lung Diseases

Organs/Tissues associated with Hpx recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >63 publications with Hpx and Liver
 Pituitary Gland Antibodies  >11 publications with Hpx and Pituitary Gland
 Ovary Antibodies  >9 publications with Hpx and Ovary
 Testis Antibodies  >7 publications with Hpx and Testis
 Pancreas Antibodies  >7 publications with Hpx and Pancreas
 Spleen Antibodies  >6 publications with Hpx and Spleen
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