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Histone H2a.v (His2Av) Drosophila Melanogaster Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1179740

MBS1179740 is a recombinant protein targeting His2Av. Also known as Recombinant Drosophila melanogaster Histone H2A.v (His2Av). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$680 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Histone H2A.v (His2Av), Recombinant Protein
Full Product Name
Recombinant Drosophila melanogaster Histone H2A.v (His2Av)
Product Gene Name
His2Av recombinant protein
Sequence
AGGKAGKDSG KAKAKAVSRS ARAGLQFPVG RIHRHLKSRT TSHGRVGATA AVYSAAILEY LTAEVLELAG NASKDLKVKR ITPRHLQLAI RGDEELDSLI KATIAGGGVI PHIHKSLIGK KEETVQDPQR KGNVILSQAY
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
14,981 Da
Sequence Positions
2-141aa; Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P08985
Species
Drosophila melanogaster (Fruit fly)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of His2Av recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for His2Av. It may not necessarily be applicable to this product.

NCBI GI #
442621298
NCBI GeneID
43229
NCBI Accession #
NP_001262997.1
UniProt Primary Accession #
P08985
UniProt Secondary Accession #
Q26252; Q540X2; Q9VBB1; A0ANX7; A0ANX8; A0ANY0; A0ANY3; C0MJB2; C0MJB9
UniProt Related Accession #
P08985
GenBank Nucleotide #
NM_001276068.1
NCBI Official Full Name
histone H2A variant, isoform B
NCBI Official Synonym Full Names
Histone H2A variant
NCBI Official Symbol
His2Av
NCBI Official Synonym Symbols
5499; CG5499; DmelCG5499; gamma-H2Av; gamma-H2AV; gamma-His2Av; gamma-HIS2AV; gammaH2Av; gammaH2AV; H2A; H2A.F/Z; H2a.V; H2A.V; H2A.X; H2A.Z; H2av; H2Av; H2AV; h2AvD; H2avD; H2AvD; H2AV_DROM; H2AX; H2AZ; his; His; HIS; His2; His2A; his2Av; His2AV; HIS2AV;
UniProt Protein Name
Histone H2A.v
UniProt Synonym Protein Names
H2A.F/Z; H2A.Z
UniProt Gene Name
His2Av
UniProt Synonym Gene Names
H2AvD; His2AvD; H2A.Z
NCBI Protein Information
CG5499 gene product from transcript CG5499-RB

UniProt Comments for His2Av

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Acts as a Polycomb group (PcG) protein required to maintain the transcriptionally repressive state of homeotic genes of the animal throughout development. Required for histone H3 'Lys-9' methylation and histone H4 'Lys-12' acetylation, two modifications that are essential for heterochromatin formation. Also involved in DNA double strand break (DSB) repair. Essential for early development.
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Research Articles on His2Av

1. H2Av or H3S10 phosphorylation by JIL-1 is not required for chromatin decondensation or transcriptional elongation in Drosophila.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with His2Av recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Gonad Antibodies  >2 publications with His2Av and Gonad
 Ovary Antibodies  >1 publications with His2Av and Ovary
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