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Napsin-A (NAPSA) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1185029

MBS1185029 is a recombinant protein targeting NAPSA. Also known as Recombinant Human Napsin-A. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. May be involved in processing of pneumocyte surfactant precursors. More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Napsin-A (NAPSA), Recombinant Protein
Full Product Name
Recombinant Human Napsin-A
Product Gene Name
Product Synonym Names
Aspartyl protease 4; ASP4; Asp 4; Napsin-1TA01/TA02
Sequence
KPIFVPLSNY RDVQYFGEIG LGTPPQNFTV AFDTGSSNLW VPSRRCHFFS VPCWLHHRFD PKASSSFQAN GTKFAIQYGT GRVDGILSED KLTIGGIKGA SVIFGEALWE PSLVFAFAHF DGILGLGFPI LSVEGVRPPM DVLVEQGLLD KPVFSFYLNR DPEEPDGGEL VLGGSDPAHY IPPLTFVPVT VPAYWQIHME RVKVGPGLTL CAKGCAAILD TGTSLITGPT EEIRALHAAI GGIPLLAGEY IILCSEIPKL PAVSFLLGGV WFNLTAHDYV IQTTRNGVRL CLSGFQALDV PPPAGPFWIL GDVFLGTYVA VFDRGDMKSS ARVGLARART RGADLGWGET AQAQFPG
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
42.5 kDa
Sequence Positions
64-420aa; Full Length
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
605631
3D Structure
ModBase 3D Structure for O96009

Product Categories/Family for NAPSA recombinant protein

ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for NAPSA recombinant protein

Napsins new human aspartic proteinases. Distinction between two closely related genes.Tatnell P.J., Powell D.J., Hill J., Smith T.S., Tew D.G., Kay J.FEBS Lett. 441:43-48(1998) Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas.Chuman Y., Bergman A.-C., Ueno T., Saito S., Sakaguchi K., Alaiya A.A., Franzen B., Bergman T., Arnott D., Auer G., Appella E., Joernvall H., Linder S.FEBS Lett. 462:129-134(1999) Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.Yan R., Bienkowski M.J., Shuck M.E., Miao H., Tory M.C., Pauley A.M., Brashier J.R., Stratman N.C., Mathews W.R., Buhl A.E., Carter D.B., Tomasselli A.G., Parodi L.A., Heinrikson R.L., Gurney M.E.Nature 402:533-537(1999) New human aspartic proteases napsin 1 and napsin 2 molecular cloning and intracellular localization of napsin 1.Koelsch G., Wu S., Henthorn J., Tang J., Lin X.

Other Notes

Small volumes of NAPSA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NAPSA. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
napsin-A preproprotein
NCBI Official Synonym Full Names
napsin A aspartic peptidase
NCBI Official Symbol
NAPSA
NCBI Official Synonym Symbols
KAP; Kdap; NAP1; NAPA; SNAPA
UniProt Protein Name
Napsin-A
UniProt Synonym Protein Names
Aspartyl protease 4; ASP4; Asp 4; Napsin-1; TA01/TA02
Protein Family
UniProt Gene Name
NAPSA
UniProt Synonym Gene Names
NAP1; NAPA; ASP4; Asp 4
UniProt Entry Name
NAPSA_HUMAN
NCBI Protein Information
napsin-A

NCBI Summary for NAPSA

The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. [provided by RefSeq, Jul 2008]
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UniProt Comments for NAPSA

NAPSA: May be involved in processing of pneumocyte surfactant precursors. Belongs to the peptidase A1 family.

Protein type: Protease; EC 3.4.23.-; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: extracellular space; lysosome

Molecular Function: aspartic-type endopeptidase activity; endopeptidase activity; peptidase activity

Biological Process: cellular protein metabolic process; membrane protein proteolysis; protein catabolic process; proteolysis; surfactant homeostasis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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