Human H2AFB2 Recombinant Protein – Cat# MBS1187937

Histone H2A-Bbd Type 2/3 (H2AFB2) Human Recombinant Protein

Name: H2AFB2 Recombinant Protein; Histone H2A-Bbd Type 2/3; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1187937
Price: 740 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1187937

$740 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Histone H2A-Bbd type 2/3 (H2AFB2), Recombinant Protein

Full Product Name

Recombinant Human Histone H2A-Bbd type 2/3 (H2AFB2)

Product Gene Name

H2AFB2 recombinant protein

Sequence

MPRRRRRRGS SGAGGRGRTC SRTVRAELSF SVSQVERSLR EGHYAQRLSR TAPVYLAAVI EYLTAKVLEL AGNEAQNSGE RNITPLLLDM VVHNDRLLST LFNTTTISQV APGED

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

12,713 Da

Sequence Positions

1-115, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

300445

3D Structure

ModBase 3D Structure for P0C5Z0

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of H2AFB2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for H2AFB2 purchase

MBS1187937 is a recombinant protein targeting H2AFB2. Also known as Recombinant Human Histone H2A-Bbd type 2/3 (H2AFB2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for H2AFB2. It may not necessarily be applicable to this product.

NCBI GI #

63029943

NCBI GeneID

474381

NCBI Accession #

NP_001017991.1

UniProt Primary Accession #

P0C5Z0

UniProt Secondary Accession #

P98176; Q5TZB2; Q6FG78; Q96PR7; A1L4E4

UniProt Related Accession #

P0C5Z0

GenBank Nucleotide #

NM_001017991.2

NCBI Official Full Name

histone H2A-Bbd type 2/3

NCBI Official Synonym Full Names

H2A histone family member B2

NCBI Official Symbol

H2AFB2

NCBI Official Synonym Symbols

H2A.Bbd

UniProt Protein Name

Histone H2A-Bbd type 2/3

UniProt Synonym Protein Names

H2A Barr body-deficient; H2A.Bbd

Protein Family

Histone

UniProt Gene Name

H2AFB2

UniProt Synonym Gene Names

H2ABBD; H2AFB; H2A.Bbd

NCBI Protein Information

histone H2A-Bbd type 2/3

NCBI Summary for H2AFB2

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the middle copy. [provided by RefSeq, Oct 2015]

UniProt Comments for H2AFB2

Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis.

Research Articles on H2AFB2

1. Changes in exon inclusion rates and increased presence of intronic sequences in mRNA products upon H2A.Bbd depletion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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