ERAD-Associated E3 Ubiquitin-Protein Ligase Hrd1 (hrd1) Schizosaccharomyces Pombe Recombinant Protein

Function: E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the hrd1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M)

By similarity. Together with ubc7, required for the degradation of the transcription factor sre1 precursor in the absence of its binding partner scp1. Ref.3

Pathway: Protein modification; protein ubiquitination.

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

Potential.

Sequence similarities: Belongs to the HRD1 family.Contains 1 RING-type zinc finger.