Human GRIN2D Recombinant Protein – Cat# MBS1195712

Glutamate [NMDA] Receptor Subunit Epsilon-4 (GRIN2D) Human Recombinant Protein

Name: GRIN2D Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1195712
Price: 1350 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1195712

MBS1195712 is a recombinant protein targeting GRIN2D. Also known as Recombinant Human Glutamate [NMDA] receptor subunit epsilon-4 (GRIN2D) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1350 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glutamate [NMDA] receptor subunit epsilon-4 (GRIN2D), Recombinant Protein

Full Product Name

Recombinant Human Glutamate [NMDA] receptor subunit epsilon-4 (GRIN2D) , partial

Product Gene Name

GRIN2D recombinant protein

Sequence

FPEEAPGPGG AGGPGGGLGG ARPLNVALVF SGPAYAAEAA RLGPAVAAAV RSPGLDVRPV ALVLNGSDPR SLVLQLCDLL SGLRVHGVVF EDDSRAPAVA PILDFLSAQT SLPIVAVHGG AALVLTPKEK GSTFLQLGSS TEQQLQVIFE VLEEYDWTSF VAVTTRAPGH RAFLSYIEVL TDGSLVGWEH RGALTLDPGA GEAVLSAQLR SVSAQIRLLF CAREEAEPVF RAAEEAGLTG SGYVWFMVGP QLAGGGGSGA PGEPPLLPGG APLPAGLFAV RSAGWRDDLA RRVAAGVAVV ARGAQALLRD YGFLPELGHD CRAQNRTHRG ESLHRYFMNI TWDNRDYSFN EDGFLVNPSL VVISLTRDRT WEVVGSWEQQ TLRLKYPLWS RYGRFLQPVD DTQHLTVATL EERPFVIVEP ADPISGTCIR DSVPCRSQLN RTHSPPPDAP RPEKRCCKGF CIDILKRLAH TIGFSYDLYL VTNGKHGKKI DGVWNGMIGE VFYQRADMAI GSLTINEERS EIVDFSVPFV ETGISVMVAR SNGTVSPSAF LEPYSPA

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

143,752 Da

Sequence Positions

28-584. partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

602717

3D Structure

ModBase 3D Structure for O15399

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GRIN2D recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GRIN2D. It may not necessarily be applicable to this product.

NCBI GI #

153946391

NCBI GeneID

2906

NCBI Accession #

NP_000827.2

UniProt Primary Accession #

O15399

UniProt Related Accession #

O15399

GenBank Nucleotide #

NM_000836.2

NCBI Official Full Name

glutamate receptor ionotropic, NMDA 2D

NCBI Official Synonym Full Names

glutamate ionotropic receptor NMDA type subunit 2D

NCBI Official Symbol

GRIN2D

NCBI Official Synonym Symbols

EB11; NR2D; EIEE46; GluN2D; NMDAR2D

UniProt Protein Name

Glutamate receptor ionotropic, NMDA 2D

UniProt Synonym Protein Names

EB11; Glutamate [NMDA] receptor subunit epsilon-4; N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NR2D

Protein Family

Glutamate receptor ionotropic

UniProt Gene Name

GRIN2D

UniProt Synonym Gene Names

GluN2D; NMDAR2D; GluN2D; NMDAR2D; NR2D

NCBI Protein Information

glutamate receptor ionotropic, NMDA 2D

NCBI Summary for GRIN2D

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]

UniProt Comments for GRIN2D

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750).

Research Articles on GRIN2D

1. High GRIN2D expression is associated with colorectal cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GRIN2D recombinant protein

Reference Product	PubMed Publications
GRIN1 recombinant protein	>5 publications with GRIN2D and GRIN1

Pathways associated with GRIN2D recombinant protein

Products by Pathway	Pathway Diagram
Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies	Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
Alcoholism Pathway antibodies	Alcoholism Pathway Diagram
Alcoholism Pathway antibodies	Alcoholism Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimer's Disease Pathway antibodies	Alzheimer's Disease Pathway Diagram
Alzheimers Disease Pathway antibodies	Alzheimers Disease Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
Amphetamine Addiction Pathway antibodies	Amphetamine Addiction Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram

Diseases associated with GRIN2D recombinant protein

Disease Name	Pubmed Publications
Schizophrenia Antibodies	>6 publications with GRIN2D and Schizophrenia
Nervous System Diseases Antibodies	>1 publications with GRIN2D and Nervous System Diseases
Brain Diseases Antibodies	>1 publications with GRIN2D and Brain Diseases
Seizures Antibodies	>1 publications with GRIN2D and Seizures

Organs/Tissues associated with GRIN2D recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>8 publications with GRIN2D and Brain