Human CHRNA3 Recombinant Protein – Cat# MBS1196219

Neuronal Acetylcholine Receptor Subunit Alpha-3 (CHRNA3) Human Recombinant Protein

Name: CHRNA3 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1196219
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1196219

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3), Recombinant Protein

Full Product Name

Recombinant Human Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3)

Product Gene Name

CHRNA3 recombinant protein

Product Synonym Gene Name

CHRNA3; NACHRA3

Product Synonym Names

Recombinant Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3); Neuronal acetylcholine receptor subunit alpha-3

Sequence

SEAEHRLFER LFEDYNEIIR PVANVSDPVI IHFEVSMSQL VKVDEVNQIM ETNLWLKQIW NDYKLKWNPS DYGGAEFMRV PAQKIWKPDI VLYNNAVGDF QVDDKTKALL KYTGEVTWIP PAIFKSSCKI DVTYFPFDYQ NCTMKFGSWS YDKAKIDLVL IGSSMNLKDY WESGEWAIIK APGYKHDIKY NCCEEIYPDI TYSLYIRRL

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

26.0 kDa

Sequence Positions

32-240. Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 15; NC_000015.9 (78885394..78913637, complement). Location: 15q24

OMIM

118503

3D Structure

ModBase 3D Structure for P32297

Species

Homo sapiens (Human)

Production Note

Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for CHRNA3 recombinant protein

Neuroscience

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CHRNA3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHRNA3 purchase

MBS1196219 is a recombinant protein targeting CHRNA3. Also known as Recombinant Human Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for CHRNA3. It may not necessarily be applicable to this product.

NCBI GI #

19923122

NCBI GeneID

1136

NCBI Accession #

NP_000734.2

UniProt Primary Accession #

P32297

UniProt Secondary Accession #

Q15823; Q4KMN8; Q86U77; Q96RH3; Q99553; Q9BQ93; Q9BRR4

UniProt Related Accession #

P32297

GenBank Nucleotide #

NM_000743.4

NCBI Official Full Name

neuronal acetylcholine receptor subunit alpha-3 isoform 1

NCBI Official Synonym Full Names

cholinergic receptor, nicotinic, alpha 3 (neuronal)

NCBI Official Symbol

CHRNA3

NCBI Official Synonym Symbols

LNCR2; PAOD2; NACHRA3

UniProt Protein Name

Neuronal acetylcholine receptor subunit alpha-3

Protein Family

Neuronal acetylcholine receptor

UniProt Gene Name

CHRNA3

UniProt Synonym Gene Names

NACHRA3

UniProt Entry Name

ACHA3_HUMAN

NCBI Protein Information

neuronal acetylcholine receptor subunit alpha-3; cholinergic receptor, nicotinic, alpha polypeptide 3; neuronal nicotinic acetylcholine receptor, alpha3 subunit

NCBI Summary for CHRNA3

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

UniProt Comments for CHRNA3

nAChRA3: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 3/CHRNA3 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Channel, cation; Membrane protein, multi-pass; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; cell soma; dendrite; postsynaptic density; plasma membrane; integral to membrane; cell junction

Molecular Function: acetylcholine receptor activity; acetylcholine binding; nicotinic acetylcholine-activated cation-selective channel activity; ligand-gated ion channel activity

Biological Process: regulation of smooth muscle contraction; nervous system development; transmembrane receptor protein tyrosine kinase activation (dimerization); regulation of acetylcholine secretion; regulation of dendrite morphogenesis; behavioral response to nicotine; locomotory behavior; signal transduction; synaptic transmission, cholinergic; synaptic transmission; regulation of membrane potential; ion transport; synaptic transmission involved in micturition; regulation of excitatory postsynaptic membrane potential

Disease: Smoking As A Quantitative Trait Locus 3

Research Articles on CHRNA3

1. Expression of alpha-3 neuronal nicotinic acetylcholine receptor subunit in sympathetic ganglia remains stable after brain death and determines the feasibility of sympathetic thoracic ganglia as a study group.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CHRNA3 recombinant protein

Reference Product	PubMed Publications
CHRNB4 recombinant protein	>62 publications with CHRNA3 and CHRNB4

Pathways associated with CHRNA3 recombinant protein

Products by Pathway	Pathway Diagram
Acetylcholine Binding And Downstream Events Pathway antibodies	Acetylcholine Binding And Downstream Events Pathway Diagram
Activation Of Nicotinic Acetylcholine Receptors Pathway antibodies	Activation Of Nicotinic Acetylcholine Receptors Pathway Diagram
Cholinergic Synapse Pathway antibodies	Cholinergic Synapse Pathway Diagram
Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway antibodies	Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway Diagram
Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies	Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway antibodies	Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram

Diseases associated with CHRNA3 recombinant protein

Disease Name	Pubmed Publications
Substance-Related Disorders Antibodies	>32 publications with CHRNA3 and Substance-Related Disorders
Neoplasms Antibodies	>30 publications with CHRNA3 and Neoplasms
Tobacco Use Disorder Antibodies	>27 publications with CHRNA3 and Tobacco Use Disorder
Lung Neoplasms Antibodies	>26 publications with CHRNA3 and Lung Neoplasms
Adenocarcinoma Antibodies	>8 publications with CHRNA3 and Adenocarcinoma
Alcoholism Antibodies	>5 publications with CHRNA3 and Alcoholism
TOBACCO ADDICTION, SUSCEPTIBILITY TO Antibodies	>3 publications with CHRNA3 and TOBACCO ADDICTION, SUSCEPTIBILITY TO
Cardiovascular Diseases Antibodies	>3 publications with CHRNA3 and Cardiovascular Diseases
Seizures Antibodies	>3 publications with CHRNA3 and Seizures
Inflammation Antibodies	>2 publications with CHRNA3 and Inflammation

Organs/Tissues associated with CHRNA3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>46 publications with CHRNA3 and Nerve
Lung Antibodies	>46 publications with CHRNA3 and Lung
Brain Antibodies	>18 publications with CHRNA3 and Brain
Blood Antibodies	>9 publications with CHRNA3 and Blood
Prostate Antibodies	>1 publications with CHRNA3 and Prostate
Stomach Antibodies	>1 publications with CHRNA3 and Stomach
Eye Antibodies	>1 publications with CHRNA3 and Eye