Mouse BTNL2 Recombinant Protein – Cat# MBS1196390

Butyrophilin-Like Protein 2 (BTNL2) Mouse Recombinant Protein

Name: BTNL2 Recombinant Protein; Butyrophilin-Like Protein 2; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1196390
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1196390

MBS1196390 is a recombinant protein targeting Btnl2. Also known as Recombinant Mouse Butyrophilin-like protein 2 (Btnl2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Butyrophilin-like protein 2 (Btnl2), Recombinant Protein

Full Product Name

Recombinant Mouse Butyrophilin-like protein 2 (Btnl2)

Product Gene Name

Btnl2 recombinant protein

Product Synonym Gene Name

Btnl2; Gm315; Ng9

Product Synonym Names

Butyrophilin-like protein 2

Sequence

MVDCPRYSLS GVAASFLFVL LTIKHPDDFR VVGPNLPILA KVGEDALLTC QLLPKRTTAH MEVRWYRSDP DMPVIMYRDG AEVTGLPMEG YGGRAEWMED STEEGSVALK IRQVQPSDDG QYWCRFQEGD YWRETSVLLQ VAALGSSPNI HVEGLGEGEV QLVCTSRGWF PEPEVHWEGI WGEKLMSFSE NHVPGEDGLF YVEDTLMVRN DSVETISCFI YSHGLRETQE ATIALSERLQ TELASVSVIG HSQPSPVQVG ENIELTCHLS PQTDAQNLEV RWLRSRYYPA VHVYANGTHV AGEQMVEYKG RTSLVTDAIH EGKLTLQIHN ARTSDEGQYR CLFGKDGVYQ EARVDVQVMA VGSTPRITRE VLKDGGMQLR CTSDGWFPRP HVQWRDRDGK TMPSFSEAFQ QGSQELFQVE TLLLVTNGSM VNVTCSISLP LGQEKTARFP LSGW

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

58,038 Da

Sequence Positions

1-454

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for O70355

Species

Mus musculus (Mouse)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Btnl2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Btnl2. It may not necessarily be applicable to this product.

NCBI GI #

83721945

NCBI GeneID

547431

NCBI Accession #

NP_524574.1

UniProt Primary Accession #

O70355

UniProt Secondary Accession #

Q3UW94; A6X8K1

UniProt Related Accession #

O70355

GenBank Nucleotide #

NM_079835.2

NCBI Official Full Name

butyrophilin-like protein 2

NCBI Official Synonym Full Names

butyrophilin-like 2

NCBI Official Symbol

Btnl2

NCBI Official Synonym Symbols

NG9; Btl2; BTLN2; Gm315; BTL-II

UniProt Protein Name

Butyrophilin-like protein 2

Protein Family

Butyrophilin-like protein

UniProt Gene Name

Btnl2

UniProt Synonym Gene Names

Gm315; Ng9

UniProt Entry Name

BTNL2_MOUSE

NCBI Protein Information

butyrophilin-like protein 2; butyrophylin-like MHC class II associated

UniProt Comments for Btnl2

BTNL2: Negative regulator of T-cell proliferation. Genetic variation in BTNL2 is a cause of susceptibility to sarcoidosis type 2 (SS2). Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis. Belongs to the immunoglobulin superfamily. BTN/MOG family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: membrane; integral to membrane

Molecular Function: receptor binding

Biological Process: negative regulation of T cell receptor signaling pathway; positive regulation of T cell proliferation

Research Articles on Btnl2

1. Butyrophilin-like 2 modulates B7 costimulation to induce Foxp3 expression and regulatory T cell development in mature T cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Btnl2 recombinant protein

Disease Name	Pubmed Publications
Sarcoidosis Antibodies	>38 publications with Btnl2 and Sarcoidosis
Lung Diseases Antibodies	>14 publications with Btnl2 and Lung Diseases
Intestinal Diseases Antibodies	>9 publications with Btnl2 and Intestinal Diseases
Colitis Antibodies	>7 publications with Btnl2 and Colitis
Necrosis Antibodies	>6 publications with Btnl2 and Necrosis
Inflammation Antibodies	>4 publications with Btnl2 and Inflammation
Death Antibodies	>1 publications with Btnl2 and Death
Drug-Related Side Effects and Adverse Reactions Antibodies	>1 publications with Btnl2 and Drug-Related Side Effects and Adverse Reactions
Prostatic Diseases Antibodies	>1 publications with Btnl2 and Prostatic Diseases
Fibrosis Antibodies	>1 publications with Btnl2 and Fibrosis

Organs/Tissues associated with Btnl2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>4 publications with Btnl2 and Intestine
Lymph Node Antibodies	>2 publications with Btnl2 and Lymph Node
Spleen Antibodies	>1 publications with Btnl2 and Spleen