Phospholipase A2 F6a (CB) Crotalus Durissus Collilineatus Recombinant Protein

Heterodimer CA-CB: Crotoxin is a potent presynaptic neurotoxin that possesses phospholipase A2 (PLA2) activity and exerts a lethal action by blocking neuromuscular transmission (PubMed:17203389, PubMed:16003952). It consists of a non-covalent association of a basic and weakly toxic PLA2 subunit (CB), with a small acidic, non-enzymatic and non-toxic subunit (CA also named crotapotin). The complex acts by binding to a specific 48-kDa protein (R48) receptor located on presynaptic membranes, forming a transient ternary complex CA-CB-R48, followed by dissociation of the CA-CB complex and release of the CA subunit. At equilibrium, only the CB subunits remain associated with the specific crotoxin receptor. In addition to neurotoxicity, crotoxin has been found to exert nephrotoxicity, and cardiovascular toxicity. Moreover, anti-inflammatory, immunomodulatory, anti-tumor and analgesic effects of crotoxin have also been reported ().