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NKG2-F Type II Integral Membrane Protein (KLRC4) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1198611

MBS1198611 is a recombinant protein targeting KLRC4. Also known as Recombinant Human NKG2-F type II integral membrane protein (KLRC4). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NKG2-F type II integral membrane protein (KLRC4), Recombinant Protein
Full Product Name
Recombinant Human NKG2-F type II integral membrane protein (KLRC4)
Product Gene Name
KLRC4 recombinant protein
Product Synonym Gene Name
KLRC4; NKG2F
Product Synonym Names
NKG2-F type II integral membrane protein; NK cell receptor F; NKG2-F-activating NK receptor
Sequence
CIGVL EQNNFSLNRR MQKARHCGHC PEEWITYSNS CYYIGKERRT WEERVCWPVL RRTLICFL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
18,234 Da
Sequence Positions
96-158
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
602893
3D Structure
ModBase 3D Structure for O43908
Species
Homo sapiens (Human)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of KLRC4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KLRC4. It may not necessarily be applicable to this product.

NCBI GI #
7710124
NCBI GeneID
8302
NCBI Accession #
NP_038459.1
UniProt Primary Accession #
O43908
UniProt Secondary Accession #
O60851
UniProt Related Accession #
O43908
GenBank Nucleotide #
NM_013431.2
NCBI Official Full Name
NKG2-F type II integral membrane protein
NCBI Official Synonym Full Names
killer cell lectin-like receptor subfamily C, member 4
NCBI Official Symbol
KLRC4
NCBI Official Synonym Symbols
NKG2F; NKG2-F
UniProt Protein Name
NKG2-F type II integral membrane protein
UniProt Synonym Protein Names
NK cell receptor F; NKG2-F-activating NK receptor
Protein Family
NKG2-F type II integral membrane protein
UniProt Gene Name
KLRC4
UniProt Synonym Gene Names
NKG2F
UniProt Entry Name
NKG2F_HUMAN
NCBI Protein Information
NKG2-F type II integral membrane protein; NK cell receptor F; natual killer cell group 2-F; NKG2-F-activating NK receptor

NCBI Summary for KLRC4

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010]
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UniProt Comments for KLRC4

KLRC4: May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2-p12.3

Cellular Component: integral to membrane

Biological Process: cellular defense response

Research Articles on KLRC4

1. NKG2F was expressed on surface of human blood NK cells, and may be up-regulated at mRNA level and protein level after IL-2 or IL-15 stimulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KLRC4 recombinant protein

 Reference Product  PubMed Publications
 TYROBP recombinant protein  >1 publications with KLRC4 and TYROBP
 HLA-C recombinant protein  >1 publications with KLRC4 and HLA-C

Pathways associated with KLRC4 recombinant protein

 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram

Diseases associated with KLRC4 recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >4 publications with KLRC4 and Cardiovascular Diseases
 Eye Diseases Antibodies  >4 publications with KLRC4 and Eye Diseases
 Behcet Syndrome Antibodies  >4 publications with KLRC4 and Behcet Syndrome
 Thrombosis Antibodies  >1 publications with KLRC4 and Thrombosis
 Leukemia, Lymphocytic, Chronic, B-Cell Antibodies  >1 publications with KLRC4 and Leukemia, Lymphocytic, Chronic, B-Cell
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