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Centromere/Kinetochore Protein Zw10 Homolog (ZW10) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1199367

This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to… More details

$1645 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Centromere/kinetochore protein zw10 homolog (ZW10), Recombinant Protein
Full Product Name
Recombinant Human Centromere/kinetochore protein zw10 homolog (ZW10)
Product Gene Name
ZW10 recombinant protein
Sequence
ASFVTEVLAH SGRLEKEDLG TRISRLTRRV EEIKGEVCNM ISKKYSEFLP SMQSAQGLIT QVDKLSEDID LLKSRIESEV RRDLHVSTGE FTDLKQQLER DSVVLSLLKQ LQEFSTAIEE YNCALTEKKY VTGAQRLEEA QKCLKLLKSR KCFDLKILKS LSMELTIQKQ NILYHLGEEW QKLIVWKFPP SKDTSSLESY LQTELHLYTE QSHKEEKTPM PPISSVLLAF SVLGELHSKL KSFGQMLLKY ILRPLASCPS LHAVIESQPN IVIIRFESIM TNLEYPSPSE VFTKIRLVLE VLQKQLLDLP LDTDLENEKT STVPLAEMLG DMIWEDLSEC LIKNCLVYSI PTNSSKLQQY EEIIQSTEEF ENALKEMRFL KGDTTDLLKY ARNINSHFAN KKCQDVIVAA RNLMTSEIHN TVKIIPDSKI NVPELPTPDE DNKLEVQKVS NTQYHEVMNL EPENTLDQHS FSLPTCRISE SVKKLMELAY QTLLEATTSS DQCAVQLFYS VRNIFHLFHD VVPTYHKENL QKLPQLAAIH HNNCMYIAHH LLTLGHQFRL RLAPILCDGT ATFVDLVPGF RRLGTECFLA QMRAQKGELL ERLSSARNFS NMDDEENYSA ASKAVRQVLH QLKRLGIVWQ DVLPVNIYCK AMGTLLNTAI SEVIGKITAL EDISTEDGDR LYSLCKTVMD EGPQVFAPLS EESKNKKYQE EVPVYVPKWM PFKELMMMLQ ASLQEIGDRW ADGKGPLAAA FSSSEVKALI RALFQNTERR AAALAKIK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
76,807 Da
Sequence Positions
2-779, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
603954
3D Structure
ModBase 3D Structure for O43264
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of ZW10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ZW10 purchase

MBS1199367 is a recombinant protein targeting ZW10. Also known as Recombinant Human Centromere/kinetochore protein zw10 homolog (ZW10). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for ZW10. It may not necessarily be applicable to this product.

NCBI GI #
4759344
NCBI GeneID
9183
NCBI Accession #
NP_004715.1
UniProt Primary Accession #
O43264
UniProt Secondary Accession #
A1A528
UniProt Related Accession #
O43264
GenBank Nucleotide #
NM_004724.3
NCBI Official Full Name
centromere/kinetochore protein zw10 homolog
NCBI Official Synonym Full Names
zw10 kinetochore protein
NCBI Official Symbol
ZW10
NCBI Official Synonym Symbols
HZW10; KNTC1AP
UniProt Protein Name
Centromere/kinetochore protein zw10 homolog
Protein Family
Centromere/kinetochore protein
UniProt Gene Name
ZW10
NCBI Protein Information
centromere/kinetochore protein zw10 homolog

NCBI Summary for ZW10

This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]

UniProt Comments for ZW10

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241).
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Research Articles on ZW10

1. The RZZ complex was purified to homogeneity and subjected to systemic crystallization.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ZW10 recombinant protein

 Reference Product  PubMed Publications
 ZWILCH recombinant protein  >23 publications with ZW10 and ZWILCH
 ZWINT recombinant protein  >15 publications with ZW10 and ZWINT
 RINT1 recombinant protein  >11 publications with ZW10 and RINT1
 NDC80 recombinant protein  >6 publications with ZW10 and NDC80
 KNTC1 recombinant protein  >2 publications with ZW10 and KNTC1
 MAD1L1 recombinant protein  >1 publications with ZW10 and MAD1L1
 INCENP recombinant protein  >1 publications with ZW10 and INCENP

Pathways associated with ZW10 recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 Resolution Of Sister Chromatid Cohesion Pathway antibodies  Resolution Of Sister Chromatid Cohesion Pathway Diagram
 Separation Of Sister Chromatids Pathway antibodies  Separation Of Sister Chromatids Pathway Diagram

Diseases associated with ZW10 recombinant protein

 Disease Name  Pubmed Publications
 Musculoskeletal Diseases Antibodies  >1 publications with ZW10 and Musculoskeletal Diseases
 Osteosarcoma Antibodies  >1 publications with ZW10 and Osteosarcoma

Organs/Tissues associated with ZW10 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with ZW10 and Brain
 Embryonic Tissue Antibodies  >2 publications with ZW10 and Embryonic Tissue
 Blood Antibodies  >1 publications with ZW10 and Blood
 Testis Antibodies  >1 publications with ZW10 and Testis
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