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STAT3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS120037

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell… More details

$575 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
STAT3, Monoclonal Antibody
Full Product Name
Mouse monoclonal antibody Anti-Human STAT3
Product Gene Name
anti-STAT3 antibody
Product Synonym Names
signal transducer and activator of transcription 3 (acute-phase response factor); APRF; FLJ20882; MGC16063
Clonality
Monoclonal
Isotype
IgG1
Clone Number
STAAD22A
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Molecular Weight
83,126 Da
OMIM
102582
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Applications Tested/Suitable for anti-STAT3 antibody
ELISA (EIA), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS)

Quality Control of anti-STAT3 antibody

Western blot analysis of immunized recombinant protein, using anti-STAT3 monoclonal antibody.
Mouse Anti-STAT3 Monoclonal Antibody – Cat# MBS120037

Quality Control #2 of anti-STAT3 antibody

Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
Mouse Anti-STAT3 Monoclonal Antibody, Quality Control #2 – Cat# MBS120037

Western Blot (WB) of anti-STAT3 antibody

Detection of STAT3 by Western blot.

Samples: Whole cell lysate from human HeLa (H, 25 ug), mouse NIH3T3 (M, 50 ug) and rat F2408 (R, 50 ug) cells. [Lot No. STAAD22A-2]

Predicted molecular weight: 87 kDa
Mouse Anti-STAT3 Monoclonal Antibody, Western Blot (WB) – Cat# MBS120037

Immunoprecipitation (IP) of anti-STAT3 antibody

Immunoprecipitation: RIPA lysate of HeLa cells was incubated with anti-STAT3 mAb. [Lot No. STAAD22A-2]

Predicted molecular weight: 87 kDa
Mouse Anti-STAT3 Monoclonal Antibody, Immunoprecipitation (IP) – Cat# MBS120037

Flow Cytometry (FC/FACS) of anti-STAT3 antibody

HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with anti-STAT3 mAb (shaded) or isotype control (unshaded) followed by Alexa Fluor(R) 488-conjugated goat anti-mouse IgG. [Lot No. STAAD22A-2]
Mouse Anti-STAT3 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS120037

Immunocytochemistry (ICC) of anti-STAT3 antibody

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-STAT3 mAb. [Lot No. STAAD22A-1]
Mouse Anti-STAT3 Monoclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS120037

Other Notes

Small volumes of anti-STAT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STAT3 purchase

MBS120037 is an antibody targeting STAT3. Also known as Mouse monoclonal antibody Anti-Human STAT3. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for STAT3. It may not necessarily be applicable to this product.

NCBI GI #
33988567
NCBI GeneID
6774
NCBI Accession #
BC000627
UniProt Secondary Accession #
O14916; Q9BW54; A8K7B8; K7ENL3
UniProt Related Accession #
P40763
NCBI Official Full Name
Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor), mRNA
NCBI Official Synonym Full Names
signal transducer and activator of transcription 3 (acute-phase response factor)
NCBI Official Symbol
STAT3
NCBI Official Synonym Symbols
APRF; HIES; ADMIO
UniProt Protein Name
Signal transducer and activator of transcription 3
UniProt Synonym Protein Names
Acute-phase response factor
Protein Family
Signal transducer and activator of transcription
UniProt Gene Name
STAT3
UniProt Entry Name
STAT3_HUMAN
NCBI Protein Information
signal transducer and activator of transcription 3; DNA-binding protein APRF; acute-phase response factor

UniProt Comments for STAT3

STAT3: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Transcription factor; DNA-binding; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: nucleoplasm; cytoplasm; mitochondrial inner membrane; plasma membrane; nucleus; cytosol

Molecular Function: protein dimerization activity; signal transducer activity; ligand-dependent nuclear receptor activity; protein binding; DNA binding; sequence-specific DNA binding; transcription factor binding; protein kinase binding; transcription factor activity; protein phosphatase binding; CCR5 chemokine receptor binding; glucocorticoid receptor binding

Biological Process: transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; viral reproduction; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; radial glial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; thermoregulation; glucose homeostasis; signal transduction; response to estradiol stimulus; negative regulation of cell proliferation; astrocyte differentiation; regulation of transcription, DNA-dependent; protein import into nucleus; acute-phase response; negative regulation of glycolysis; positive regulation of Notch signaling pathway; response to drug; nervous system development; intracellular receptor-mediated signaling pathway; eating behavior; cytokine and chemokine mediated signaling pathway; regulation of multicellular organism growth; JAK-STAT cascade; cellular response to hormone stimulus; regulation of transcription from RNA polymerase II promoter; cell proliferation; response to ethanol; sexual reproduction; positive regulation of transcription from RNA polymerase II promoter; eye photoreceptor cell differentiation; cell motility; phosphorylation

Disease: Hyper-ige Recurrent Infection Syndrome, Autosomal Dominant; Autoimmune Disease, Multisystem, Infantile-onset
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Research Articles on STAT3

1. High STAT3 induces anoikis resistance, promotes cell invasion and metastatic potential in pancreatic cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STAT3 antibody

 Reference Product  PubMed Publications
 STAT1 antibody  >1784 publications with STAT3 and STAT1
 JAK2 antibody  >1504 publications with STAT3 and JAK2
 SRC antibody  >820 publications with STAT3 and SRC
 JAK1 antibody  >617 publications with STAT3 and JAK1
 CCND1 antibody  >516 publications with STAT3 and CCND1
 EGFR antibody  >471 publications with STAT3 and EGFR
 MTOR antibody  >248 publications with STAT3 and MTOR
 PIAS3 antibody  >94 publications with STAT3 and PIAS3
 LEP antibody  >16 publications with STAT3 and LEP
 EP300 antibody  >11 publications with STAT3 and EP300

Pathways associated with anti-STAT3 antibody

 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram

Diseases associated with anti-STAT3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1917 publications with STAT3 and Inflammation
 Carcinoma Antibodies  >1608 publications with STAT3 and Carcinoma
 Necrosis Antibodies  >842 publications with STAT3 and Necrosis
 Adenocarcinoma Antibodies  >711 publications with STAT3 and Adenocarcinoma
 Breast Neoplasms Antibodies  >515 publications with STAT3 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >506 publications with STAT3 and Neoplasms, Experimental
 Autoimmune Diseases Antibodies  >430 publications with STAT3 and Autoimmune Diseases
 Liver Neoplasms Antibodies  >427 publications with STAT3 and Liver Neoplasms
 Lung Neoplasms Antibodies  >384 publications with STAT3 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >340 publications with STAT3 and Neoplasm Metastasis

Organs/Tissues associated with anti-STAT3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2845 publications with STAT3 and Blood
 Liver Antibodies  >1377 publications with STAT3 and Liver
 Brain Antibodies  >1111 publications with STAT3 and Brain
 Vascular Antibodies  >991 publications with STAT3 and Vascular
 Lung Antibodies  >878 publications with STAT3 and Lung
 Muscle Antibodies  >822 publications with STAT3 and Muscle
 Bone Antibodies  >783 publications with STAT3 and Bone
 Heart Antibodies  >596 publications with STAT3 and Heart
 Skin Antibodies  >527 publications with STAT3 and Skin
 Bone Marrow Antibodies  >515 publications with STAT3 and Bone Marrow
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