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CHD1L Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS120146

MBS120146 is an antibody targeting CHD1L. Also known as Mouse monoclonal antibody Anti-Human CHD1L. Reactive in Human. Host: Mouse. More details

$575 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CHD1L, Monoclonal Antibody
Full Product Name
Mouse monoclonal antibody Anti-Human CHD1L
Product Gene Name
anti-CHD1L antibody
Product Synonym Names
Homo sapiens chromodomain helicase DNA binding protein 1-like (CHD1L); ALC1; CHDL; FLJ22530
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2170C3a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Molecular Weight
69,139 Da
OMIM
613039
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Applications Tested/Suitable for anti-CHD1L antibody
Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB)

Quality Control of anti-CHD1L antibody

Left: Western blot analysis of immunized recombinant protein, using anti-CHD1L monoclonal antibody.
Mouse Anti-CHD1L Monoclonal Antibody – Cat# MBS120146

Western Blot (WB) of anti-CHD1L antibody

Detection of human CHD1L by Western blot.

Samples: Whole cell lysate (25 ug) from HEK293 cells. [Lot No. 2170C3a-1]

Predicted molecular weight: 101 kDa
Mouse Anti-CHD1L Monoclonal Antibody, Western Blot (WB) – Cat# MBS120146

Immunoprecipitation (IP) of anti-CHD1L antibody

Immunoprecipitation: RIPA lysate of HeLa cells was incubated with anti-CHD1L mAb. [Lot No. 2170C3a-1]

Predicted molecular weight: 101 kDa
Mouse Anti-CHD1L Monoclonal Antibody, Immunoprecipitation (IP) – Cat# MBS120146

Immunocytochemistry (ICC) of anti-CHD1L antibody

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-CHD1L mAb. [Lot No. 2170C3a-1]
Mouse Anti-CHD1L Monoclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS120146

Other Notes

Small volumes of anti-CHD1L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CHD1L. It may not necessarily be applicable to this product.

NCBI GI #
373428659
NCBI GeneID
9557
NCBI Accession #
NP_004275.4
UniProt Secondary Accession #
Q53EZ3; Q5VXX7; Q6DD94; Q6PK83; Q86XH3; Q96HF7; Q96SP3; Q9BVJ1; A5YM64; B4DDE1; B5MDZ7
UniProt Related Accession #
Q86WJ1
GenBank Nucleotide #
NM_004284
NCBI Official Full Name
Homo sapiens chromodomain helicase DNA binding protein 1-like (CHD1L), transcript variant 1, mRNA
NCBI Official Synonym Full Names
chromodomain helicase DNA binding protein 1-like
NCBI Official Symbol
CHD1L
NCBI Official Synonym Symbols
ALC1; CHDL
UniProt Protein Name
Chromodomain-helicase-DNA-binding protein 1-like
UniProt Synonym Protein Names
Amplified in liver cancer protein 1
Protein Family
Chromodomain-helicase-DNA-binding protein
UniProt Gene Name
CHD1L
UniProt Entry Name
CHD1L_HUMAN
NCBI Protein Information
chromodomain-helicase-DNA-binding protein 1-like; amplified in liver cancer 1; amplified in liver cancer protein 1

NCBI Summary for CHD1L

This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012]

UniProt Comments for CHD1L

CHD1L: DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding. Belongs to the SNF2/RAD54 helicase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; EC 3.6.4.12; Helicase

Chromosomal Location of Human Ortholog: 1q12

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; nucleus

Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; ATPase activity; nucleotide binding; ATP binding

Biological Process: chromatin remodeling; DNA repair; response to DNA damage stimulus; DNA duplex unwinding
Show more

Research Articles on CHD1L

1. CHD1L is now considered to be a novel independent biomarker for progression, prognosis and survival in several solid tumors. [Review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CHD1L antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >18 publications with CHD1L and Carcinoma
 Carcinoma, Hepatocellular Antibodies  >15 publications with CHD1L and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >11 publications with CHD1L and Liver Neoplasms
 Liver Diseases Antibodies  >10 publications with CHD1L and Liver Diseases
 Adenocarcinoma Antibodies  >9 publications with CHD1L and Adenocarcinoma
 Mental Disorders Antibodies  >2 publications with CHD1L and Mental Disorders
 Neoplasm Metastasis Antibodies  >2 publications with CHD1L and Neoplasm Metastasis
 Urinary Bladder Diseases Antibodies  >2 publications with CHD1L and Urinary Bladder Diseases
 Liver Neoplasms, Experimental Antibodies  >1 publications with CHD1L and Liver Neoplasms, Experimental
 Nervous System Diseases Antibodies  >1 publications with CHD1L and Nervous System Diseases

Organs/Tissues associated with anti-CHD1L antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >14 publications with CHD1L and Liver
 Kidney Antibodies  >2 publications with CHD1L and Kidney
 Vascular Antibodies  >2 publications with CHD1L and Vascular
 Embryonic Tissue Antibodies  >2 publications with CHD1L and Embryonic Tissue
 Heart Antibodies  >1 publications with CHD1L and Heart
 Bone Antibodies  >1 publications with CHD1L and Bone
 Uterus Antibodies  >1 publications with CHD1L and Uterus
 Blood Antibodies  >1 publications with CHD1L and Blood
 Cervix Antibodies  >1 publications with CHD1L and Cervix
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