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BCL9 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS120150

BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies.… More details

$575 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BCL9, Monoclonal Antibody
Full Product Name
Mouse monoclonal antibody Anti-Human BCL9
Product Gene Name
anti-BCL9 antibody
Product Synonym Names
Homo sapiens B-cell CLL/lymphoma 9 (BCL9); LGS; MGC131591
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2071C3a
Host
Mouse
Species Reactivity
Human
Form/Format
Mouse monoclonal anti-human BCL9 antibody in PBS (3.0 mM KCI,1.5 mM KH2PO4 140mM NaCI, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3)
Preparation and Storage
Store at 2-8°C for up to one year.
We recommend storing at -20°C for long term storage.
Avoid repeat freezing and thawing cycles.
OMIM
602597
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Immmunogen
Recombinant
Sterility
Filtered through a 0.22 um membrane.
Disposal
This antibody solution contains sodium azide (NaN3) as a preservative. There is a potential hazard that NaN3 reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water.
Note
Caution must be taken to avoid contact with skin or eyes. In such case, rinse thoroughly at once with water. Do not ingest, inhale, or swallow. Seek medical attention inmediately. Wear appopiate protective clothing such as laboratory overalls, safety glasses and gloves. It is strongly advised that this product should be handled by people who have been well trained laboratory techniques and that is handled with care pursuant to the principles of good laboratory practice. All chemicals are deemed potentially harmful.

The vial is prone to fall over. Use caution, especially when the lid is off.
Applications Tested/Suitable for anti-BCL9 antibody
Dot Blot (DB)

Quality Control of anti-BCL9 antibody

Western blot analysis of immunized recombinant protein, using anti-BCL9 monoclonal antibody.
Mouse Anti-BCL9 Monoclonal Antibody – Cat# MBS120150

Quality Control #2 of anti-BCL9 antibody

Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
Mouse Anti-BCL9 Monoclonal Antibody, Quality Control #2 – Cat# MBS120150

Other Notes

Small volumes of anti-BCL9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCL9 purchase

MBS120150 is an antibody targeting BCL9. Also known as Mouse monoclonal antibody Anti-Human BCL9. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for BCL9. It may not necessarily be applicable to this product.

NCBI GI #
523425752
NCBI GeneID
607
NCBI Accession #
NP_004317.2
UniProt Secondary Accession #
Q5T489
UniProt Related Accession #
O00512
GenBank Nucleotide #
NM_004326
NCBI Official Full Name
Homo sapiens B-cell CLL/lymphoma 9 (BCL9), mRNA
NCBI Official Synonym Full Names
B-cell CLL/lymphoma 9
NCBI Official Symbol
BCL9
NCBI Official Synonym Symbols
LGS
UniProt Protein Name
B-cell CLL/lymphoma 9 protein
UniProt Synonym Protein Names
Protein legless homolog
Protein Family
B-cell CLL/lymphoma 9 protein
UniProt Gene Name
BCL9
UniProt Entry Name
BCL9_HUMAN
NCBI Protein Information
B-cell CLL/lymphoma 9 protein; B-cell lymphoma 9 protein; bcl-9; protein legless homolog

UniProt Comments for BCL9

Bcl-9: Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity. A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies. Belongs to the BCL9 family.

Protein type: Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; Golgi apparatus; cis-Golgi network

Molecular Function: protein binding; beta-catenin binding

Biological Process: regulation of transforming growth factor beta receptor signaling pathway; somatic stem cell maintenance; myotube differentiation involved in skeletal muscle regeneration; positive regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin
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Research Articles on BCL9

1. By beta-catenin's association with LEF1 and BCL9-2/B9L.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BCL9 antibody

 Reference Product  PubMed Publications
 CTNNB1 antibody  >50 publications with BCL9 and CTNNB1
 PYGO1 antibody  >8 publications with BCL9 and PYGO1
 PYGO2 antibody  >6 publications with BCL9 and PYGO2
 TCF4 antibody  >4 publications with BCL9 and TCF4
 TCF7L2 antibody  >4 publications with BCL9 and TCF7L2

Pathways associated with anti-BCL9 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By WNT In Cancer Pathway antibodies  Signaling By WNT In Cancer Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
 XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway antibodies  XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway Diagram
 Deactivation Of The Beta-catenin Transactivating Complex Pathway antibodies  Deactivation Of The Beta-catenin Transactivating Complex Pathway Diagram

Diseases associated with anti-BCL9 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >9 publications with BCL9 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >4 publications with BCL9 and Neoplasm Metastasis
 Neovascularization, Pathologic Antibodies  >3 publications with BCL9 and Neovascularization, Pathologic
 Liver Diseases Antibodies  >2 publications with BCL9 and Liver Diseases
 Ovarian Diseases Antibodies  >1 publications with BCL9 and Ovarian Diseases
 Heart Diseases Antibodies  >1 publications with BCL9 and Heart Diseases
 Depressive Disorder Antibodies  >1 publications with BCL9 and Depressive Disorder
 Puberty, Delayed Antibodies  >1 publications with BCL9 and Puberty, Delayed
 Hyperplasia Antibodies  >1 publications with BCL9 and Hyperplasia
 Necrosis Antibodies  >1 publications with BCL9 and Necrosis

Organs/Tissues associated with anti-BCL9 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >6 publications with BCL9 and Bone
 Liver Antibodies  >5 publications with BCL9 and Liver
 Brain Antibodies  >4 publications with BCL9 and Brain
 Intestine Antibodies  >3 publications with BCL9 and Intestine
 Eye Antibodies  >3 publications with BCL9 and Eye
 Embryonic Tissue Antibodies  >3 publications with BCL9 and Embryonic Tissue
 Placenta Antibodies  >2 publications with BCL9 and Placenta
 Lung Antibodies  >2 publications with BCL9 and Lung
 Heart Antibodies  >2 publications with BCL9 and Heart
 Muscle Antibodies  >2 publications with BCL9 and Muscle
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