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DHX38 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS120170

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and… More details

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Product Overview

Online Datasheet in PDF
Product Name
DHX38, Monoclonal Antibody
Full Product Name
Mouse monoclonal antibody Anti-Human DHX38
Product Gene Name
anti-DHX38 antibody
Product Synonym Names
Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 38 (DHX38), mRNA; DDX38; PRP16; PRPF16; KIAA0224
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2271C1a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Molecular Weight
60,743 Da
OMIM
605584
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Applications Tested/Suitable for anti-DHX38 antibody
Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS)

Quality Control of anti-DHX38 antibody

Left: Western blot analysis of immunized recombinant protein, using anti-DHX38 monoclonal antibody.
Mouse Anti-DHX38 Monoclonal Antibody – Cat# MBS120170

Western Blot (WB) of anti-DHX38 antibody

Detection of DHX38 by Western blot.

Samples: Whole cell lysate from human HeLa (H, 50 ug), mouse NIH3T3 (M, 50 ug) and rat F2408 (R, 50 ug) cells. [Lot No. 2271C1a-1]

Predicted molecular weight: 140 kDa
Mouse Anti-DHX38 Monoclonal Antibody, Western Blot (WB) – Cat# MBS120170

Immunoprecipitation (IP) of anti-DHX38 antibody

Immunoprecipitation: RIPA lysate of HeLa cells was incubated with anti-DHX38 mAb. [Lot No. 2271C1a-1]

Predicted molecular weight: 140 kDa
Mouse Anti-DHX38 Monoclonal Antibody, Immunoprecipitation (IP) – Cat# MBS120170

Flow Cytometry (FC/FACS) of anti-DHX38 antibody

HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with anti-DHX38 mAb (shaded) or isotype control (unshaded) followed by Alexa Fluor(R) 488-conjugated goat anti-mouse IgG. [Lot No. 2271C1a-1]
Mouse Anti-DHX38 Monoclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS120170

Immunocytochemistry (ICC) of anti-DHX38 antibody

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-DHX38 mAb. [Lot No. 2271C1a-1]
Mouse Anti-DHX38 Monoclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS120170

Other Notes

Small volumes of anti-DHX38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DHX38 purchase

MBS120170 is an antibody targeting DHX38. Also known as Mouse monoclonal antibody Anti-Human DHX38. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DHX38. It may not necessarily be applicable to this product.

NCBI GI #
41406095
NCBI GeneID
9785
NCBI Accession #
NP_054722.2
UniProt Secondary Accession #
O75212; Q96HN7; B4DVG8; D3DWS7
UniProt Related Accession #
Q92620
GenBank Nucleotide #
NM_014003
NCBI Official Full Name
Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 38 (DHX38), mRNA
NCBI Official Synonym Full Names
DEAH (Asp-Glu-Ala-His) box polypeptide 38
NCBI Official Symbol
DHX38
NCBI Official Synonym Symbols
DDX38; PRP16; PRPF16
UniProt Protein Name
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
UniProt Synonym Protein Names
ATP-dependent RNA helicase DHX38; DEAH box protein 38
UniProt Gene Name
DHX38
UniProt Entry Name
PRP16_HUMAN
NCBI Protein Information
pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; ATP-dependent RNA helicase DHX38; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 38; DEAH box protein 38; PRP16 homolog of S.cerevisiae; pre-mRNA splicing factor ATP-dependent RNA helicase PRP16

UniProt Comments for DHX38

DHX38: Probable ATP-binding RNA helicase involved in pre-mRNA splicing. Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.

Protein type: EC 3.6.4.13; RNA processing; RNA splicing; RNA-binding; Helicase; Spliceosome

Chromosomal Location of Human Ortholog: 16q22

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus

Molecular Function: protein binding; ATP-dependent RNA helicase activity; ATP binding

Biological Process: nuclear mRNA splicing, via spliceosome; transcription from RNA polymerase II promoter; mRNA export from nucleus; RNA splicing; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription
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Research Articles on DHX38

1. DHX38 is the first pre-mRNA splicing gene that is putatively associated with autosomal-recessive inherited retinitis pigmentosa.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DHX38 antibody

 Reference Product  PubMed Publications
 CDC40 antibody  >1 publications with DHX38 and CDC40
 PRPF8 antibody  >1 publications with DHX38 and PRPF8
 GPKOW antibody  >1 publications with DHX38 and GPKOW

Pathways associated with anti-DHX38 antibody

 Products by Pathway  Pathway Diagram
 Cleavage Of Growing Transcript In The Termination Region Pathway antibodies  Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 RNA Polymerase II Transcription Pathway antibodies  RNA Polymerase II Transcription Pathway Diagram
 RNA Polymerase II Transcription Termination Pathway antibodies  RNA Polymerase II Transcription Termination Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Transport Of Mature Transcript To Cytoplasm Pathway antibodies  Transport Of Mature Transcript To Cytoplasm Pathway Diagram
 Transport Of Mature MRNA Derived From An Intron-Containing Transcript Pathway antibodies  Transport Of Mature MRNA Derived From An Intron-Containing Transcript Pathway Diagram
 MRNA 3'-end Processing Pathway antibodies  MRNA 3'-end Processing Pathway Diagram

Diseases associated with anti-DHX38 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >1 publications with DHX38 and Congenital Abnormalities
 Death Antibodies  >1 publications with DHX38 and Death
 Weight Gain Antibodies  >1 publications with DHX38 and Weight Gain

Organs/Tissues associated with anti-DHX38 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with DHX38 and Eye
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