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LSM8 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS120174

This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
LSM8, Monoclonal Antibody
Full Product Name
Mouse monoclonal antibody Anti-Human LSM8
Product Gene Name
anti-LSM8 antibody
Product Synonym Names
Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) (LSM8); YJR022W
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2527C6a
Host
Mouse
Species Reactivity
Human
Form/Format
Mouse monoclonal anti-human LSM8 antibody in PBS (3.0 mM KCI, 1.5 mM KH2PO4, 140 mM NaCl, 8.0 mM Na2HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3)
Concentration
100 ug/ml (1.0 ml) (lot specific)
Preparation and Storage
Store at 2-8°C for up to one year.
We recommend storing at -20°C for long-term storage.
Avoid repeat freezing and thawing cycles.
OMIM
607288
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Disposal
this antibody solutions contains sodium azide (NaN3) as a preservative. There is a potential hazard NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water.
Applications Tested/Suitable for anti-LSM8 antibody
Dot Blot (DB), Immunocytochemistry (ICC)
Application Notes for anti-LSM8 antibody
ICC: 2-100 ug/ml

Quality Control of anti-LSM8 antibody

Western blot analysis of immunized recombinant protein, using anti-LSM8 monoclonal antibody.
Mouse Anti-LSM8 Monoclonal Antibody – Cat# MBS120174

Quality Control #2 of anti-LSM8 antibody

Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
Mouse Anti-LSM8 Monoclonal Antibody, Quality Control #2 – Cat# MBS120174

Immunocytochemistry (ICC) of anti-LSM8 antibody

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-LSM8 mAb. [Lot No.2527C6a-1]
Mouse Anti-LSM8 Monoclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS120174

Other Notes

Small volumes of anti-LSM8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LSM8 purchase

MBS120174 is an antibody targeting LSM8. Also known as Mouse monoclonal antibody Anti-Human LSM8. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for LSM8. It may not necessarily be applicable to this product.

NCBI GI #
284172355
NCBI GeneID
51691
NCBI Accession #
NP_057284.1
UniProt Related Accession #
O95777
GenBank Nucleotide #
NM_016200
NCBI Official Full Name
Homo sapiens LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) (LSM8), mRNA
NCBI Official Synonym Full Names
LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)
NCBI Official Symbol
LSM8
NCBI Official Synonym Symbols
LSM8; NAA38
UniProt Protein Name
U6 snRNA-associated Sm-like protein LSm8
Protein Family
Probable U6 snRNA-associated Sm-like protein
UniProt Gene Name
LSM8
UniProt Entry Name
LSM8_HUMAN
NCBI Protein Information
LSM8 homolog, U6 small nuclear RNA associated; MAK31-like protein; N-alpha-acetyltransferase 38, NatC auxiliary subunit; U6 snRNA-associated Sm-like protein LSm8

NCBI Summary for LSM8

This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010]
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UniProt Comments for LSM8

LSM8: Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family.

Protein type: RNA splicing

Chromosomal Location of Human Ortholog: 7q31.31

Cellular Component: spliceosome; U4/U6 x U5 tri-snRNP complex

Molecular Function: protein binding; U6 snRNA 3'-end binding; U6 snRNA binding

Biological Process: nuclear mRNA splicing, via spliceosome
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Research Articles on LSM8

1. LSm8 controls nuclear accumulation of all LSm2-7 proteins and the number of cytoplasmic processing bodies.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LSM8 antibody

 Reference Product  PubMed Publications
 LSM2 antibody  >8 publications with LSM8 and LSM2
 LSM7 antibody  >3 publications with LSM8 and LSM7
 LSM4 antibody  >3 publications with LSM8 and LSM4
 LSM6 antibody  >2 publications with LSM8 and LSM6
 LSM5 antibody  >2 publications with LSM8 and LSM5
 LSM3 antibody  >1 publications with LSM8 and LSM3

Pathways associated with anti-LSM8 antibody

 Products by Pathway  Pathway Diagram
 Lsm 2-8 Complex Pathway antibodies  Lsm 2-8 Complex Pathway Diagram
 Lsm 2-8 Complex Pathway antibodies  Lsm 2-8 Complex Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome, U4/U6.U5 Tri-snRNP Pathway antibodies  Spliceosome, U4/U6.U5 Tri-snRNP Pathway Diagram
 Spliceosome, U4/U6.U5 Tri-snRNP Pathway antibodies  Spliceosome, U4/U6.U5 Tri-snRNP Pathway Diagram

Diseases associated with anti-LSM8 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with LSM8 and Nervous System Diseases

Organs/Tissues associated with anti-LSM8 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1 publications with LSM8 and Brain
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