FER Antibody – Mouse Monoclonal

Fer: a non-receptor tyrosine kinase of the Fer family. Regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Increased expression associated with prostate cancer proliferation, and antisense blocks soft agar growth.

Protein type: Kinase, protein; EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Oncoprotein; TK group; Fer family

Chromosomal Location of Human Ortholog: 5q21

Cellular Component: microtubule cytoskeleton; extrinsic to internal side of plasma membrane; lamellipodium; cytoplasm; nuclear chromatin; cell cortex; cytosol; nucleus; cell junction; actin cytoskeleton

Molecular Function: protein binding; cadherin binding; protein-tyrosine kinase activity; gamma-catenin binding; non-membrane spanning protein tyrosine kinase activity; actin binding; protein kinase binding; lipid binding; protein phosphatase 1 binding; Rab GTPase binding; ATP binding; epidermal growth factor receptor binding

Biological Process: regulation of mast cell degranulation; peptidyl-tyrosine phosphorylation; diapedesis; protein amino acid autophosphorylation; tyrosine phosphorylation of Stat3 protein; negative regulation of mast cell activation during immune response; platelet-derived growth factor receptor signaling pathway; response to lipopolysaccharide; chemotaxis; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; positive regulation of cell proliferation; cell adhesion; cell differentiation; regulation of protein amino acid phosphorylation; cytokine and chemokine mediated signaling pathway; microtubule cytoskeleton organization and biogenesis; regulation of epidermal growth factor receptor signaling pathway; regulation of cell proliferation; cell proliferation; cellular response to insulin stimulus; positive regulation of actin filament polymerization; actin cytoskeleton reorganization; innate immune response; mitotic cell cycle; positive regulation of cell migration