• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CLNS1A Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS120273

The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced… More details

$575 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CLNS1A, Monoclonal Antibody
Full Product Name
Mouse monoclonal antibody Anti-Human CLNS1A
Product Gene Name
Product Synonym Names
Homo sapiens chloride channel, nucleotide-sensitive, 1A (CLNS1A); CLCI; ICln; CLNS1B
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2187C2a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Molecular Weight
26,215 Da
OMIM
602158
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Applications Tested/Suitable for anti-CLNS1A antibody
Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

Quality Control of anti-CLNS1A antibody

Western blot analysis of immunized recombinant protein, using anti-CLNS1A monoclonal antibody.
Mouse Anti-CLNS1A Monoclonal Antibody – Cat# MBS120273

Quality Control #2 of anti-CLNS1A antibody

Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
Mouse Anti-CLNS1A Monoclonal Antibody, Quality Control #2 – Cat# MBS120273

Western Blot (WB) of anti-CLNS1A antibody

Detection of CLNS1A by Western blot.

Samples: Whole cell lysate from human HEK293 (H, 25 ug), mouse NIH3T3 (M, 25 ug) and rat F2408 (R, 25 ug) cells. [Lot No. 2187C2a-1]

Predicted molecular weight: 26 kDa
Mouse Anti-CLNS1A Monoclonal Antibody, Western Blot (WB) – Cat# MBS120273

Immunocytochemistry (ICC) of anti-CLNS1A antibody

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-CLNS1A mAb. [Lot No. 2187C2a-1]
Mouse Anti-CLNS1A Monoclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS120273

Other Notes

Small volumes of anti-CLNS1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLNS1A purchase

MBS120273 is an antibody targeting CLNS1A. Also known as Mouse monoclonal antibody Anti-Human CLNS1A. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CLNS1A. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
Homo sapiens chloride channel, nucleotide-sensitive, 1A (CLNS1A), mRNA
NCBI Official Synonym Full Names
chloride channel, nucleotide-sensitive, 1A
NCBI Official Symbol
CLNS1A
NCBI Official Synonym Symbols
CLCI; ICln; CLNS1B
UniProt Protein Name
Methylosome subunit pICln
UniProt Synonym Protein Names
Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln); Chloride ion current inducer protein; ClCI; Reticulocyte pICln
UniProt Gene Name
CLNS1A
UniProt Entry Name
ICLN_HUMAN
NCBI Protein Information
methylosome subunit pICln; chloride channel regulatory protein; chloride channel, nucleotide sensitive 1A; chloride conductance regulatory protein ICln; chloride ion current inducer protein; i(Cln); reticulocyte pICln; reticulocyte protein ICln

NCBI Summary for CLNS1A

This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. [provided by RefSeq, Feb 2009]
Show more

UniProt Comments for CLNS1A

ICLN: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Belongs to the pICln (TC 1.A.47) family.

Protein type: Channel, chloride

Chromosomal Location of Human Ortholog: 11q13.5-q14

Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: protein binding

Biological Process: spliceosomal snRNP biogenesis; chloride transport; gene expression; cell volume homeostasis
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLNS1A antibody

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000