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PPP1R13L Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS120284

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53… More details

$575 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PPP1R13L, Monoclonal Antibody
Full Product Name
Mouse monoclonal antibody Anti-Human PPP1R13L
Product Gene Name
anti-PPP1R13L antibody
Product Synonym Names
Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 13 like (PPP1R13L); RAI; IASPP; NKIP1; iASPP gene
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2808C5a
Host
Mouse
Species Reactivity
Human
Concentration
100 ug/ml (1.0 ml) (lot specific)
Molecular Weight
89,091 Da
OMIM
607463
Preparation
This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Sterility
Filtered through a 0.22 um membrane.
Applications Tested/Suitable for anti-PPP1R13L antibody
Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

Quality Control of anti-PPP1R13L antibody

Western blot analysis of immunized recombinant protein, using anti-PPP1R13L monoclonal antibody.
Mouse Anti-PPP1R13L Monoclonal Antibody – Cat# MBS120284

Quality Control #2 of anti-PPP1R13L antibody

Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
Mouse Anti-PPP1R13L Monoclonal Antibody, Quality Control #2 – Cat# MBS120284

Western Blot (WB) of anti-PPP1R13L antibody

Detection of human PPP1R13L by Western blot.

Samples: Whole cell lysate (25 ug) from HeLa cells. [Lot No. 2808C5a-1]

Predicted molecular weight: 89 kDa
Mouse Anti-PPP1R13L Monoclonal Antibody, Western Blot (WB) – Cat# MBS120284

Immunocytochemistry (ICC) of anti-PPP1R13L antibody

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-PPP1R13L mAb. [Lot No.2808C5a-1]
Mouse Anti-PPP1R13L Monoclonal Antibody, Immunocytochemistry (ICC) – Cat# MBS120284

Other Notes

Small volumes of anti-PPP1R13L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPP1R13L purchase

MBS120284 is an antibody targeting PPP1R13L. Also known as Mouse monoclonal antibody Anti-Human PPP1R13L. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PPP1R13L. It may not necessarily be applicable to this product.

NCBI GI #
215820633
NCBI GeneID
10848
NCBI Accession #
NP_006654.2
UniProt Secondary Accession #
Q2PNZ9; Q5DU71; Q5I1X4; Q6P1R7; Q6PKF8; Q9Y290
UniProt Related Accession #
Q8WUF5
GenBank Nucleotide #
NM_006663
NCBI Official Full Name
Homo sapiens protein phosphatase 1, regulatory subunit 13 like (PPP1R13L), transcript variant 2, mRNA
NCBI Official Synonym Full Names
protein phosphatase 1, regulatory subunit 13 like
NCBI Official Symbol
PPP1R13L
NCBI Official Synonym Symbols
RAI; RAI4; IASPP; NKIP1
UniProt Protein Name
RelA-associated inhibitor
UniProt Synonym Protein Names
Inhibitor of ASPP protein; Protein iASPP; NFkB-interacting protein 1; PPP1R13B-like protein
Protein Family
RelA-associated inhibitor
UniProt Gene Name
PPP1R13L
UniProt Entry Name
IASPP_HUMAN
NCBI Protein Information
relA-associated inhibitor; NFkB interacting protein 1; NFkB-interacting protein 1; PPP1R13B-like protein; inhibitor of ASPP protein; inhibitor of apoptosis stimulating protein of p53; protein iASPP; protein phosphatase 1, regulatory (inhibitor) subunit 13 like; retinoic acid induced 4

NCBI Summary for PPP1R13L

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

UniProt Comments for PPP1R13L

PPP1R13L: an oncoprotein that interacts with and inhibits NF-kappaB, Sp1 and p53. Plays a central role in regulation of apoptosis and transcription. May inhibit p53 by preventing its association with ASPP1 or ASPP2, thereby suppressing the subsequent activation of apoptosis. Required for neuronal survival after axonal injury. Two alternatively spliced isoforms have been described. Isoform 1 is preferrentially found in the cytoplasm; isoform 2 is nuclear.

Protein type: Transcription, coactivator/corepressor; Apoptosis; Phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: intercellular bridge; cytoplasm; nucleus; cell junction

Molecular Function: identical protein binding; protein binding; transcription factor binding; transcription corepressor activity

Biological Process: transcription, DNA-dependent; apoptosis; multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; multicellular organismal homeostasis; embryonic camera-type eye development; cardiac muscle contraction; post-embryonic development; hair cycle
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Research Articles on PPP1R13L

1. MIRN124 binds to the 3'UTR of iASPP and suppressing mRNA expression and the proliferation of prostate tumor cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPP1R13L antibody

 Reference Product  PubMed Publications
 CD3EAP antibody  >15 publications with PPP1R13L and CD3EAP
 RELA antibody  >12 publications with PPP1R13L and RELA
 TP53 antibody  >11 publications with PPP1R13L and TP53
 TP63 antibody  >3 publications with PPP1R13L and TP63
 SP1 antibody  >2 publications with PPP1R13L and SP1

Pathways associated with anti-PPP1R13L antibody

 Products by Pathway  Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram

Diseases associated with anti-PPP1R13L antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >16 publications with PPP1R13L and Lung Diseases
 Lung Neoplasms Antibodies  >15 publications with PPP1R13L and Lung Neoplasms
 Breast Neoplasms Antibodies  >10 publications with PPP1R13L and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >6 publications with PPP1R13L and Neoplasm Metastasis
 Leukemia Antibodies  >6 publications with PPP1R13L and Leukemia
 Nervous System Diseases Antibodies  >5 publications with PPP1R13L and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >5 publications with PPP1R13L and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >4 publications with PPP1R13L and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with PPP1R13L and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >3 publications with PPP1R13L and Neoplasms, Experimental

Organs/Tissues associated with anti-PPP1R13L antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >17 publications with PPP1R13L and Lung
 Skin Antibodies  >7 publications with PPP1R13L and Skin
 Liver Antibodies  >4 publications with PPP1R13L and Liver
 Placenta Antibodies  >3 publications with PPP1R13L and Placenta
 Prostate Antibodies  >3 publications with PPP1R13L and Prostate
 Heart Antibodies  >3 publications with PPP1R13L and Heart
 Embryonic Tissue Antibodies  >3 publications with PPP1R13L and Embryonic Tissue
 Bone Antibodies  >3 publications with PPP1R13L and Bone
 Brain Antibodies  >2 publications with PPP1R13L and Brain
 Stomach Antibodies  >2 publications with PPP1R13L and Stomach
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