Immediate Early Glycoprotein (UL37) Human Cytomegalovirus Recombinant Protein

Function: Isoform vMIA sequesters proapoptotic BAX at the outer mitochondrial membrane and prevents cytochrome c release and subsequent initiation of the proapoptotic cascade. Also provoques a calcium efflux from host endoplasmic reticulum and F-actin cytoskeleton disruption. Participates in the increase of host mitochondrial biogenesis, thus promoting viral replication by efficient use of newly made mitochondria. Ref.6 Ref.7 Ref.11Isoform gpUL37 may play a role in escape from the host antiviral response. Ref.6 Ref.7 Ref.11

Subunit structure: Isofom vMIA interacts with host BAX. Isoform vMIA interacts with host RSAD2/viperin; this interaction results in RSAD2/viperin relocalization from the endoplasmic reticulum to the mitochondria, actin cytoskeleton disruption and enhancement of infection. Ref.6 Ref.10

Subcellular location: Isoform gpUL37: Host membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host mitochondrion membrane; Single-pass membrane protein. Note: The C-terminal fragment localizes to the endoplasmic reticulum while the N-terminal fragment is stable and traffics to mitochondria. Ref.5 Ref.8 Ref.9Isoform vMIA: Host mitochondrion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Note: Transported from the endoplasmic reticulum (ER) through the mitochondrial associated membrane (MAMs) to the mitochondrial outer membrane. Associates with internal lipid rafts (LRs) in the MAM. Ref.5 Ref.8 Ref.9Isoform pUL37m: Host mitochondrion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Note: Not cleaved or N-glycosylated. Ref.5 Ref.8 Ref.9

Sequence similarities: Belongs to the immediate early glycoprotein family.