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NKG2-D Type II Integral Membrane Protein (KLRK1) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1204609

MBS1204609 is a recombinant protein targeting Klrk1. Also known as Recombinant Rat NKG2-D type II integral membrane protein (Klrk1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NKG2-D type II integral membrane protein (Klrk1), Recombinant Protein
Full Product Name
Recombinant Rat NKG2-D type II integral membrane protein (Klrk1)
Product Gene Name
Klrk1 recombinant protein
Product Synonym Gene Name
Klrk1; Nkg2d; Nkrp2
Product Synonym Names
NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NK lectin-like receptor; NKLLR; NKG2-D-activating NK receptor; NKR-P2; CD_antigen=; CD314
Sequence
AVFITL LCNKEVSVSS REGYCGPCPN DWICHRNNCY QFFNENKAWN QSQASCLSQN SSLLKIYSKE EQDFLKLVKS YHWMGLVQSP ANGSWQWEDG SSLSPNELTL VKTPSGTCAV YGSSFKAYTE DCSNPNTYIC MKRAV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
24,438 Da
Sequence Positions
75-215
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for O70215
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Klrk1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Klrk1. It may not necessarily be applicable to this product.

NCBI GI #
19424150
NCBI GeneID
24934
NCBI Accession #
NP_598196.1
UniProt Primary Accession #
O70215
UniProt Related Accession #
O70215
GenBank Nucleotide #
NM_133512.2
NCBI Official Full Name
NKG2-D type II integral membrane protein
NCBI Official Synonym Full Names
killer cell lectin-like receptor subfamily K, member 1
NCBI Official Symbol
Klrk1
NCBI Official Synonym Symbols
NKG2D; Nkrp2
UniProt Protein Name
NKG2-D type II integral membrane protein
UniProt Synonym Protein Names
Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NK lectin-like receptor; NKLLR; NKG2-D-activating NK receptor; NKR-P2; CD_antigen: CD314
Protein Family
NKG2-D type II integral membrane protein
UniProt Gene Name
Klrk1
UniProt Synonym Gene Names
Nkg2d; Nkrp2; NKLLR
UniProt Entry Name
NKG2D_RAT
NCBI Protein Information
NKG2-D type II integral membrane protein; NKLLR; NK cell receptor D; NK lectin-like receptor; NKG2-D-activating NK receptor; NKR-P2, ortholog of human NKG2D

NCBI Summary for Klrk1

functions as a natural cytotoxicity receptor to stimulate perforin-mediated elimination of ligand-expressing tumor cells [RGD, Feb 2006]

UniProt Comments for Klrk1

Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8+ T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins.
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Research Articles on Klrk1

1. Blockade of NKG2D significantly attenuated ischemia-reperfusion injury in a cardiac transplantation model.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Klrk1 recombinant protein

 Reference Product  PubMed Publications
 Hcst recombinant protein  >36 publications with Klrk1 and Hcst
 Rae1 recombinant protein  >34 publications with Klrk1 and Rae1
 Ncr1 recombinant protein  >33 publications with Klrk1 and Ncr1
 Tyrobp recombinant protein  >11 publications with Klrk1 and Tyrobp
 Gzmb recombinant protein  >6 publications with Klrk1 and Gzmb
 Raet1l recombinant protein  >2 publications with Klrk1 and Raet1l

Pathways associated with Klrk1 recombinant protein

 Products by Pathway  Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Diseases associated with Klrk1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >288 publications with Klrk1 and Neoplasms
 Carcinoma Antibodies  >58 publications with Klrk1 and Carcinoma
 Gastrointestinal Diseases Antibodies  >39 publications with Klrk1 and Gastrointestinal Diseases
 Necrosis Antibodies  >38 publications with Klrk1 and Necrosis
 Inflammation Antibodies  >34 publications with Klrk1 and Inflammation
 Melanoma Antibodies  >30 publications with Klrk1 and Melanoma
 Cardiovascular Diseases Antibodies  >20 publications with Klrk1 and Cardiovascular Diseases
 Ovarian Neoplasms Antibodies  >19 publications with Klrk1 and Ovarian Neoplasms
 Nervous System Diseases Antibodies  >15 publications with Klrk1 and Nervous System Diseases
 Liver Neoplasms Antibodies  >14 publications with Klrk1 and Liver Neoplasms

Organs/Tissues associated with Klrk1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >3 publications with Klrk1 and Eye
 Pancreas Antibodies  >1 publications with Klrk1 and Pancreas
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