Human PPAP2C Recombinant Protein – Cat# MBS1207428

Lipid Phosphate Phosphohydrolase 2 (PPAP2C) Human Recombinant Protein

Name: PPAP2C Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1207428
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1207428

MBS1207428 is a recombinant protein targeting PPAP2C. Also known as Recombinant Human Lipid phosphate phosphohydrolase 2 (PPAP2C). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Lipid phosphate phosphohydrolase 2 (PPAP2C), Recombinant Protein

Full Product Name

Recombinant Human Lipid phosphate phosphohydrolase 2 (PPAP2C)

Product Gene Name

PPAP2C recombinant protein

Product Synonym Gene Name

PPAP2C; LPP2

Product Synonym Names

Recombinant Lipid phosphate phosphohydrolase 2 (PPAP2C); Lipid phosphate phosphohydrolase 2 EC= 3.1.3.4; PAP2-gamma; PAP2-G Phosphatidate phosphohydrolase type 2c Phosphatidic acid phosphatase 2c; PAP-2c; PAP2c

Sequence

MQRRWVFVLL DVLCLLVASL PFAILTLVNA PYKRGFYCGD DSIRYPYRPD TITHGLMAGV TITATVILVS AGEAYLVYTD RLYSRSDFNN YVAAVYKVLG TFLFGAAVSQ SLTDLAKYMI GRLRPNFLAV CDPDWSRVNC SVYVQLEKVC RGNPADVTEA RLSFYSGHSS FGMYCMVFLA LYVQARLCWK WARLLRPTVQ FFLVAFALYV GYTRVSDYKH HWSDVLVGLL QGALVAALTV CYISDFFKAR PPQHCLKEEE LERKPSLSLT LTLGEADHNH YGYPHSSS

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

32,574 Da

Sequence Positions

1-288

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 19; NC_000019.9 (281043..291435, complement). Location: 19p13

OMIM

607126

3D Structure

ModBase 3D Structure for O43688

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PPAP2C recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PPAP2C. It may not necessarily be applicable to this product.

NCBI GI #

4505977

NCBI GeneID

8612

NCBI Accession #

NP_003703.1

UniProt Primary Accession #

O43688

UniProt Secondary Accession #

A6NLV0

UniProt Related Accession #

O43688

GenBank Nucleotide #

NM_003712.2

NCBI Official Full Name

lipid phosphate phosphohydrolase 2 isoform 1

NCBI Official Synonym Full Names

phosphatidic acid phosphatase type 2C

NCBI Official Symbol

PPAP2C

NCBI Official Synonym Symbols

LPP2; PAP-2c; PAP2-g

UniProt Protein Name

Lipid phosphate phosphohydrolase 2

UniProt Synonym Protein Names

PAP2-gamma; PAP2-G; Phosphatidate phosphohydrolase type 2c; Phosphatidic acid phosphatase 2c

UniProt Gene Name

PPAP2C

UniProt Synonym Gene Names

LPP2; PAP2-G; PAP-2c; PAP2c

UniProt Entry Name

LPP2_HUMAN

NCBI Protein Information

lipid phosphate phosphohydrolase 2; PAP2c; PAP2-gamma; phosphatidic acid phosphatase 2c; phosphatidate phosphohydrolase type 2c; phosphatidic acid phosphohydrolase type 2c; type-2 phosphatidic acid phosphatase-gamma

NCBI Summary for PPAP2C

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

UniProt Comments for PPAP2C

PPAP2C: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. Belongs to the PA-phosphatase related phosphoesterase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Lipid Metabolism - ether lipid; Lipid Metabolism - sphingolipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Lipid Metabolism - glycerolipid; Membrane protein, multi-pass; EC 3.1.3.4; Phosphatase, lipid

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: phosphatidate phosphatase activity; phosphoprotein phosphatase activity

Biological Process: sphingolipid metabolic process; sphingolipid biosynthetic process; dephosphorylation

Research Articles on PPAP2C

1. endogenous LPP2 and LPP3 form homo- and hetero-oligomers, which differ in their subcellular localization and which may confer differing spatial regulation of phosphatidic acid and sphingosine 1-phosphate signalling

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PPAP2C recombinant protein

Products by Pathway	Pathway Diagram
Ether Lipid Metabolism Pathway antibodies	Ether Lipid Metabolism Pathway Diagram
Ether Lipid Metabolism Pathway antibodies	Ether Lipid Metabolism Pathway Diagram
Fat Digestion And Absorption Pathway antibodies	Fat Digestion And Absorption Pathway Diagram
Fat Digestion And Absorption Pathway antibodies	Fat Digestion And Absorption Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Glycerolipid Metabolism Pathway antibodies	Glycerolipid Metabolism Pathway Diagram
Glycerophospholipid Metabolism Pathway antibodies	Glycerophospholipid Metabolism Pathway Diagram
Glycerophospholipid Metabolism Pathway antibodies	Glycerophospholipid Metabolism Pathway Diagram

Diseases associated with PPAP2C recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1 publications with PPAP2C and Neoplasms
Cell Transformation, Neoplastic Antibodies	>1 publications with PPAP2C and Cell Transformation, Neoplastic