Rat ALOX5AP Recombinant Protein – Cat# MBS1209280

Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) Rat Recombinant Protein

Name: ALOX5AP Recombinant Protein; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS1209280
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1209280

MBS1209280 is a recombinant protein targeting Alox5ap. Also known as Recombinant Rat Arachidonate 5-lipoxygenase-activating protein (Alox5ap). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Arachidonate 5-lipoxygenase-activating protein (Alox5ap), Recombinant Protein

Full Product Name

Recombinant Rat Arachidonate 5-lipoxygenase-activating protein (Alox5ap)

Product Gene Name

Alox5ap recombinant protein

Product Synonym Gene Name

Alox5ap; Flap

Product Synonym Names

Recombinant Arachidonate 5-lipoxygenase-activating protein (Alox5ap); Arachidonate 5-lipoxygenase-activating protein; FLAP MK-886-binding protein

Sequence

MDQEAVGNVV LLAIVTLISV VQNAFFAHKV ELESKAQSGR SFQRTGTLAF ERVYTANQNC VDAYPTFLVV LWTAGLLCSQ VPAAFAGLMY LFVRQKYFVG YLGERTQSTP GYIFGKRIIL FLFLMSLAGI LNHYLIFFFG SDFENYIRTI TTTISPLLLI P

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

18,070 Da

Sequence Positions

1-161

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 12; NC_005111.3 (8950727..8974708, complement). Location: 12p11

3D Structure

ModBase 3D Structure for P20291

Species

Rattus norvegicus (Rat)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Alox5ap recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Alox5ap. It may not necessarily be applicable to this product.

NCBI GI #

8392897

NCBI GeneID

29624

NCBI Accession #

NP_058956.1

UniProt Primary Accession #

P20291

UniProt Secondary Accession #

Q5RJL3

UniProt Related Accession #

P20291

GenBank Nucleotide #

NM_017260.2

NCBI Official Full Name

arachidonate 5-lipoxygenase-activating protein

NCBI Official Synonym Full Names

arachidonate 5-lipoxygenase activating protein

NCBI Official Symbol

Alox5ap

UniProt Protein Name

Arachidonate 5-lipoxygenase-activating protein

UniProt Synonym Protein Names

FLAP; MK-886-binding protein

Protein Family

Arachidonate 5-lipoxygenase-activating protein

UniProt Gene Name

Alox5ap

UniProt Synonym Gene Names

Flap

UniProt Entry Name

AL5AP_RAT

NCBI Protein Information

arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein; 5-lipoxygenase-activating protein FLAP

NCBI Summary for Alox5ap

involved in leukotriene synthesis; plays a role in immediate hypersensitivity response [RGD, Feb 2006]

UniProt Comments for Alox5ap

ALOX5AP: Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition. Belongs to the MAPEG family.

Protein type: Nuclear envelope; Activator; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: endoplasmic reticulum membrane; nuclear membrane; membrane; endoplasmic reticulum; integral to membrane; nuclear envelope; cytosol; nucleus

Molecular Function: arachidonic acid binding; enzyme binding; protein homodimerization activity; glutathione transferase activity; protein heterodimerization activity; leukotriene-C4 synthase activity; arachidonate 5-lipoxygenase activity; enzyme activator activity; protein N-terminus binding; glutathione peroxidase activity

Biological Process: leukotriene biosynthetic process; positive regulation of catalytic activity; leukotriene production during acute inflammatory response; lipoxygenase pathway; positive regulation of acute inflammatory response

Research Articles on Alox5ap

1. To evaluate whether mRNA levels of Pde4d and Alox5ap were associated with hypertensive stroke and hypertension in stroke-prone renovascular hypertensive rats (RHRSP) which could simulate human being's hypertensive cerebral stroke.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Alox5ap recombinant protein

Reference Product	PubMed Publications
Alox5 recombinant protein	>195 publications with Alox5ap and Alox5
Pde4d recombinant protein	>16 publications with Alox5ap and Pde4d
Lta4h recombinant protein	>16 publications with Alox5ap and Lta4h
Ltc4s recombinant protein	>13 publications with Alox5ap and Ltc4s
Laptm5 recombinant protein	>1 publications with Alox5ap and Laptm5
Tbxas1 recombinant protein	>1 publications with Alox5ap and Tbxas1

Pathways associated with Alox5ap recombinant protein

Products by Pathway	Pathway Diagram
Arachidonic Acid Metabolism Pathway antibodies	Arachidonic Acid Metabolism Pathway Diagram
Eicosanoid Synthesis Pathway antibodies	Eicosanoid Synthesis Pathway Diagram
IL-5 Signaling Pathway antibodies	IL-5 Signaling Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Synthesis Of 5-eicosatetraenoic Acids Pathway antibodies	Synthesis Of 5-eicosatetraenoic Acids Pathway Diagram
Synthesis Of Leukotrienes (LT) And Eoxins (EX) Pathway antibodies	Synthesis Of Leukotrienes (LT) And Eoxins (EX) Pathway Diagram
Synthesis Of Lipoxins (LX) Pathway antibodies	Synthesis Of Lipoxins (LX) Pathway Diagram

Diseases associated with Alox5ap recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>94 publications with Alox5ap and Cardiovascular Diseases
Inflammation Antibodies	>80 publications with Alox5ap and Inflammation
Cerebral Infarction Antibodies	>57 publications with Alox5ap and Cerebral Infarction
Nervous System Diseases Antibodies	>54 publications with Alox5ap and Nervous System Diseases
Lung Diseases Antibodies	>51 publications with Alox5ap and Lung Diseases
Atherosclerosis Antibodies	>39 publications with Alox5ap and Atherosclerosis
Neoplasms Antibodies	>33 publications with Alox5ap and Neoplasms
Disease Models, Animal Antibodies	>18 publications with Alox5ap and Disease Models, Animal
Necrosis Antibodies	>7 publications with Alox5ap and Necrosis
Drug Toxicity Antibodies	>5 publications with Alox5ap and Drug Toxicity

Organs/Tissues associated with Alox5ap recombinant protein

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>18 publications with Alox5ap and Heart
Kidney Antibodies	>9 publications with Alox5ap and Kidney
Connective Tissue Antibodies	>7 publications with Alox5ap and Connective Tissue