Transmembrane O-Methyltransferase (LRTOMT) Macaca Mulatta Recombinant Protein

This gene encodes two different proteins. One is a leucine-rich transmembrane protein of unknown function while the other is an O-methyltransferase. Defects in the O-methyltransferase protein can cause nonsyndromic deafness in humans. Several transcript variants encoding different isoforms of each protein have been reported for this gene. [provided by RefSeq, Dec 2010]

Function: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function

By similarity. UniProtKB Q8WZ04 UniProtKB P21964

Catalytic activity: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. UniProtKB P21964

Subcellular location: Isoform 1: Membrane; Single-pass membrane protein

Potential. Isoform 2: Cytoplasm

By similarity UniProtKB A1Y9I9.

Miscellaneous: In primates, this protein is produced by a bicistronic gene which also produces the LRRC51 protein from an overlapping reading frame. In rodents, these proteins are produced by 2 separate adjacent genes which together are orthologous to the single primate gene. Ref.1

Sequence similarities: Belongs to the methyltransferase superfamily. Catechol-O-methyltransferase family.

Sequence caution: The sequence ACF40887.1 differs from that shown. Reason: Frameshift at positions 18 and 31. The sequence ACF40888.1 differs from that shown. Reason: Frameshift at position 11.