Human EI24 Recombinant Protein – Cat# MBS1211246

Etoposide-Induced Protein 2.4 Homolog (EI24) Human Recombinant Protein

Name: EI24 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1211246
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1211246

MBS1211246 is a recombinant protein targeting EI24. Also known as Recombinant Human Etoposide-induced protein 2.4 homolog (EI24). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Etoposide-induced protein 2.4 homolog (EI24), Recombinant Protein

Full Product Name

Recombinant Human Etoposide-induced protein 2.4 homolog (EI24)

Product Gene Name

EI24 recombinant protein

Product Synonym Gene Name

EI24; PIG8

Product Synonym Names

Recombinant Etoposide-induced protein 2.4 homolog (EI24); Etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein

Sequence

MADSVKTFLQ DLARGIKDSI WGICTISKLD ARIQQKREEQ RRRRASSVLA QRRAQSIERK QESEPRIVSR IFQCCAWNGG VFWFSLLLFY RVFIPVLQSV TARIIGDPSL HGDVWSWLEF FLTSIFSALW VLPLFVLSKV VNAIWFQDIA DLAFEVSGRK PHPFPSVSKI IADMLFNLLL QALFLIQGMF VSLFPIHLVG QLVSLLHMSL LYSLYCFEYR WFNKGIEMHQ RLSNIERNWP YYFGFGLPLA FLTAMQSSYI ISGCLFSILF PLFIISANEA KTPGKAYLFQ LRLFSLVVFL SNRLFHKTVY LQSALSSSTS AEKFPSPHPS PAKLKATAGH

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

38,965 Da

Sequence Positions

1-340

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 11; NC_000011.9 (125439298..125454575). Location: 11q24

OMIM

605170

3D Structure

ModBase 3D Structure for O14681

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of EI24 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EI24. It may not necessarily be applicable to this product.

NCBI GI #

55956768

NCBI GeneID

9538

NCBI Accession #

NP_001007278.1

UniProt Primary Accession #

O14681

UniProt Secondary Accession #

Q9BUQ1; A8K7D6

UniProt Related Accession #

O14681

GenBank Nucleotide #

NM_001007277.1

NCBI Official Full Name

etoposide-induced protein 2.4 homolog isoform 2

NCBI Official Synonym Full Names

etoposide induced 2.4

NCBI Official Symbol

EI24

NCBI Official Synonym Symbols

EPG4; PIG8; TP53I8

UniProt Protein Name

Etoposide-induced protein 2.4 homolog

UniProt Synonym Protein Names

p53-induced gene 8 protein

Protein Family

Etoposide-induced protein

UniProt Gene Name

EI24

UniProt Synonym Gene Names

PIG8

UniProt Entry Name

EI24_HUMAN

NCBI Protein Information

etoposide-induced protein 2.4 homolog; etoposide induced 2.4 mRNA; p53-induced gene 8 protein; tumor protein p53 inducible protein 8; ectopic P-granules autophagy protein 4 homolog

NCBI Summary for EI24

This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for EI24

EI24: a p53-induced gene that appears to play a role in p53-mediated events. May activate apoptosis and reduce tumor invasiveness. Mutations in its gene have been associated with breast cancer.

Protein type: Membrane protein, multi-pass; Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; nuclear membrane; membrane; endoplasmic reticulum; cytoplasm; integral to membrane

Biological Process: response to drug; DNA damage response, signal transduction resulting in induction of apoptosis; apoptosis; autophagy; negative regulation of cell growth; neuromuscular process controlling balance

Research Articles on EI24

1. our data suggest that inactivation of EI24 and CHEK1 through two independent mechanisms contributes to the development of CACX.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with EI24 recombinant protein

Products by Pathway	Pathway Diagram
P53 Signaling Pathway antibodies	P53 Signaling Pathway Diagram
P53 Signaling Pathway antibodies	P53 Signaling Pathway Diagram

Diseases associated with EI24 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>5 publications with EI24 and Neoplasms
Skin Diseases Antibodies	>3 publications with EI24 and Skin Diseases
Breast Neoplasms Antibodies	>3 publications with EI24 and Breast Neoplasms
Necrosis Antibodies	>3 publications with EI24 and Necrosis
Carcinoma Antibodies	>2 publications with EI24 and Carcinoma
Hyperglycemia Antibodies	>1 publications with EI24 and Hyperglycemia
Neoplasm Metastasis Antibodies	>1 publications with EI24 and Neoplasm Metastasis
Neoplasms, Experimental Antibodies	>1 publications with EI24 and Neoplasms, Experimental
Hypertension Antibodies	>1 publications with EI24 and Hypertension

Organs/Tissues associated with EI24 recombinant protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>2 publications with EI24 and Eye
Muscle Antibodies	>2 publications with EI24 and Muscle
Nerve Antibodies	>2 publications with EI24 and Nerve
Bone Antibodies	>1 publications with EI24 and Bone
Lymph Node Antibodies	>1 publications with EI24 and Lymph Node
Embryonic Tissue Antibodies	>1 publications with EI24 and Embryonic Tissue
Vascular Antibodies	>1 publications with EI24 and Vascular
Liver Antibodies	>1 publications with EI24 and Liver
Intestine Antibodies	>1 publications with EI24 and Intestine