Human PECAM1 Recombinant Protein – Cat# MBS1212159

Platelet Endothelial Cell Adhesion Molecule (PECAM1) Human Recombinant Protein

Name: PECAM1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1212159
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1212159

MBS1212159 is a recombinant protein targeting PECAM1. Also known as Recombinant Human Platelet endothelial cell adhesion molecule (PECAM1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Platelet endothelial cell adhesion molecule (PECAM1), Recombinant Protein

Full Product Name

Recombinant Human Platelet endothelial cell adhesion molecule (PECAM1)

Product Gene Name

PECAM1 recombinant protein

Product Synonym Names

Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD_antigen=; CD31

Sequence

QEN SFTINSVDMK SLPDWTVQNG KNLTLQCFAD VSTTSHVKPQ HQMLFYKDDV LFYNISSMKS TESYFIPEVR IYDSGTYKCT VIVNNKEKTT AEYQLLVEGV PSPRVTLDKK EAIQGGIVRV NCSVPEEKAP IHFTIEKLEL NEKMVKLKRE KNSRDQNFVI LEFPVEEQDR VLSFRCQARI ISGIHMQTSE STKSELVTVT ESFSTPKFHI SPTGMIMEGA QLHIKCTIQV THLAQEFPEI IIQKDKAIVA HNRHGNKAVY SVMAMVEHSG NYTCKVESSR ISKVSSIVVN ITELFSKPEL ESSFTHLDQG ERLNLSCSIP GAPPANFTIQ KEDTIVSQTQ DFTKIASKSD SGTYICTAGI DKVVKKSNTV QIVVCEMLSQ PRISYDAQFE VIKGQTIEVR CESISGTLPI SYQLLKTSKV LENSTKNSND PAVFKDNPTE DVEYQCVADN CHSHAKMLSE VLRVKVIAPV DEVQISILSS KVVESGEDIV LQCAVNEGSG PITYKFYREK EGKPFYQMTS NATQAFWTKQ KASKEQEGEY YCTAFNRANH ASSVPRSKIL TVRVILAPWK K

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

81,378 Da

Sequence Positions

28-601

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

173445

3D Structure

ModBase 3D Structure for P16284

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PECAM1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PECAM1. It may not necessarily be applicable to this product.

NCBI GI #

313760624

NCBI GeneID

5175

NCBI Accession #

NP_000433.4

UniProt Primary Accession #

P16284

UniProt Secondary Accession #

Q6LDA9; Q8TBH1; Q96RF5; Q96RF6; Q9NP65; Q9NPB7; Q9NPG9; Q9NQS9; Q9NQT0; A8K3S7; D3DU31

UniProt Related Accession #

P16284

GenBank Nucleotide #

NM_000442.4

NCBI Official Full Name

platelet endothelial cell adhesion molecule

NCBI Official Synonym Full Names

platelet/endothelial cell adhesion molecule 1

NCBI Official Symbol

PECAM1

NCBI Official Synonym Symbols

CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM

UniProt Protein Name

Platelet endothelial cell adhesion molecule

UniProt Synonym Protein Names

EndoCAM; GPIIA'; PECA1; CD_antigen: CD31

Protein Family

Platelet endothelial cell adhesion molecule

UniProt Gene Name

PECAM1

UniProt Synonym Gene Names

PECAM-1

UniProt Entry Name

PECA1_HUMAN

NCBI Protein Information

platelet endothelial cell adhesion molecule; CD31 antigen

NCBI Summary for PECAM1

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]

UniProt Comments for PECAM1

PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: extracellular space; platelet alpha granule membrane; plasma membrane; integral to membrane; cell junction

Molecular Function: protein binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; diapedesis; cell recognition; blood coagulation; cell adhesion; signal transduction; leukocyte migration; phagocytosis

Research Articles on PECAM1

1. results of the current meta-analysis suggest that homozygous polymorphic genotype (GG) of the rs1131012 SNP may confer protection against myocardial infarction

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PECAM1 recombinant protein

Reference Product	PubMed Publications
CD38 recombinant protein	>63 publications with PECAM1 and CD38
SRC recombinant protein	>58 publications with PECAM1 and SRC
CTNNB1 recombinant protein	>42 publications with PECAM1 and CTNNB1
PTPN11 recombinant protein	>33 publications with PECAM1 and PTPN11
PTPN6 recombinant protein	>17 publications with PECAM1 and PTPN6
CSK recombinant protein	>6 publications with PECAM1 and CSK
FYN recombinant protein	>5 publications with PECAM1 and FYN
ITGB3 recombinant protein	>4 publications with PECAM1 and ITGB3
LYN recombinant protein	>3 publications with PECAM1 and LYN
JUP recombinant protein	>3 publications with PECAM1 and JUP

Pathways associated with PECAM1 recombinant protein

Products by Pathway	Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Integrin Cell Surface Interactions Pathway antibodies	Integrin Cell Surface Interactions Pathway Diagram
Leukocyte Transendothelial Migration Pathway antibodies	Leukocyte Transendothelial Migration Pathway Diagram
Leukocyte Transendothelial Migration Pathway antibodies	Leukocyte Transendothelial Migration Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
PECAM1 Interactions Pathway antibodies	PECAM1 Interactions Pathway Diagram

Diseases associated with PECAM1 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1570 publications with PECAM1 and Neoplasms
Inflammation Antibodies	>443 publications with PECAM1 and Inflammation
Necrosis Antibodies	>373 publications with PECAM1 and Necrosis
Neoplasms, Experimental Antibodies	>235 publications with PECAM1 and Neoplasms, Experimental
Neoplasm Metastasis Antibodies	>228 publications with PECAM1 and Neoplasm Metastasis
Lung Diseases Antibodies	>211 publications with PECAM1 and Lung Diseases
Heart Diseases Antibodies	>210 publications with PECAM1 and Heart Diseases
Breast Neoplasms Antibodies	>187 publications with PECAM1 and Breast Neoplasms
Lung Neoplasms Antibodies	>164 publications with PECAM1 and Lung Neoplasms
Liver Diseases Antibodies	>149 publications with PECAM1 and Liver Diseases

Organs/Tissues associated with PECAM1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>3069 publications with PECAM1 and Vascular
Blood Antibodies	>2726 publications with PECAM1 and Blood
Muscle Antibodies	>607 publications with PECAM1 and Muscle
Bone Marrow Antibodies	>397 publications with PECAM1 and Bone Marrow
Lung Antibodies	>384 publications with PECAM1 and Lung
Heart Antibodies	>313 publications with PECAM1 and Heart
Brain Antibodies	>289 publications with PECAM1 and Brain
Liver Antibodies	>270 publications with PECAM1 and Liver
Umbilical Cord Antibodies	>216 publications with PECAM1 and Umbilical Cord
Kidney Antibodies	>215 publications with PECAM1 and Kidney