Regenerating Islet-Derived Protein 3-Gamma (REG3G) Mouse Recombinant Protein

Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L. monocytogenes and methicillin-resistant S. aureus. Regulates keratinocyte proliferation and differentiation after skin injury

Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma.Narushima Y., Unno M., Nakagawara K., Mori M., Miyashita H., Suzuki Y., Noguchi N., Takasawa S., Kumagai T., Yonekura H., Okamoto H.Gene 185:159-168(1997) Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment.Mukherjee S., Partch C.L., Lehotzky R.E., Whitham C.V., Chu H., Bevins C.L., Gardner K.H., Hooper L.V.J. Biol. Chem. 284:4881-4888(2009) Refolding, purification, and characterization of human and murine RegIII proteins expressed in Escherichia coli.Cash H.L., Whitham C.V., Hooper L.V.Protein Expr. Purif. 48:151-159(2006) Symbiotic bacteria direct expression of an intestinal bactericidal lectin.Cash H.L., Whitham C.V., Behrendt C.L., Hooper L.V.Science 313:1126-1130(2006) MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection.Brandl K., Plitas G., Schnabl B., De;Matteo R.P., Pamer E.G.J. Exp. Med. 204:1891-1900(2007) The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine.Vaishnava S., Yamamoto M., Severson K.M., Ruhn K.A., Yu X., Koren O., Ley R., Wakeland E.K., Hooper L.V.Science 334:255-258(2011) The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury.Lai Y., Li D., Li C., Muehleisen B., Radek K.A., Park H.J., Jiang Z., Li Z., Lei H., Quan Y., Zhang T., Wu Y., Kotol P., Morizane S., Hata T.R., Iwatsuki K., Tang C., Gallo R.L.Immunity 37:74-84(2012) Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia.Choi S.M., McAleer J.P., Zheng M., Pociask D.A., Kaplan M.H., Qin S., Reinhart T.A., Kolls J.K.J. Exp. Med. 210:551-561(2013)

Small volumes of Reg3g recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1213774 is a recombinant protein targeting Reg3g. Also known as Recombinant Mouse Regenerating islet-derived protein 3-gamma. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.