Protein Vpx (vpx) Recombinant Protein

Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.

A novel proviral clone of HIV-2 biological and phylogenetic relationship to other primate immunodeficiency viruses.Kirchhoff F., Jentsch K., Bachmann B., Stuke A., Laloux C., Lueke W., Stahl-Henning C., Schneider J., Nieselt K., Eigen M., Hunsmann G.Virology 177:305-311(1990) The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection.Bergamaschi A., Ayinde D., David A., Le Rouzic E., Morel M., Collin G., Descamps D., Damond F., Brun-Vezinet F., Nisole S., Margottin-Goguet F., Pancino G., Transy C.J. Virol. 83:4854-4860(2009) AIDS/HIV. HIV interplay with SAMHD1.Schaller T., Goujon C., Malim M.H.Science 335:1313-1314(2012) The Vpx lentiviral accessory protein targets SAMHD1 for degradation in the nucleus.Hofmann H., Logue E.C., Bloch N., Daddacha W., Polsky S.B., Schultz M.L., Kim B., Landau N.R.J. Virol. 86:12552-12560(2012)

Small volumes of vpx recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1215666 is a recombinant protein targeting vpx. Also known as Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.