Frataxin, Mitochondrial (FXN) Rat Recombinant Protein

FXN: Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity)

Protein type: EC 1.16.3.1; Mitochondrial; Motility/polarity/chemotaxis

Cellular Component: mitochondrion; cell; cytosol

Molecular Function: metallochaperone activity; 2 iron, 2 sulfur cluster binding; ferroxidase activity; enzyme binding; ferric iron binding; ferrous iron binding; iron-sulfur cluster binding

Biological Process: cellular iron ion homeostasis; positive regulation of axon extension; proprioception; adult walking behavior; response to organic cyclic substance; protein autoprocessing; embryonic development ending in birth or egg hatching; iron incorporation into metallo-sulfur cluster; positive regulation of lyase activity; positive regulation of cell proliferation; response to iron ion; oxidative phosphorylation; positive regulation of oxidoreductase activity; response to drug; mitochondrion organization and biogenesis; negative regulation of multicellular organism growth; iron-sulfur cluster assembly; positive regulation of transferase activity; positive regulation of metalloenzyme activity; negative regulation of organ growth; positive regulation of cell growth; aerobic respiration; ion transport; negative regulation of apoptosis; heme biosynthetic process