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Protein Lifeguard 2 (FAIM2) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1221802

MBS1221802 is a recombinant protein targeting Faim2. Also known as Recombinant Rat Protein lifeguard 2 (Faim2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Protein lifeguard 2 (Faim2), Recombinant Protein
Full Product Name
Recombinant Rat Protein lifeguard 2 (Faim2)
Product Gene Name
Faim2 recombinant protein
Product Synonym Gene Name
Faim2; Lfg, Lfg2, Nmp35
Product Synonym Names
Recombinant Protein lifeguard 2 (Faim2); Protein lifeguard 2; Fas apoptotic inhibitory molecule 2 Neural membrane protein 35
Sequence
MTQGKLSVAN KAPGTEGQQQ ANGEKKDAPA VPSAPPSYEE ATSGEGLKAG AFPQGPTAVP LHPSWAYVDP SSSSGYEGGF PAGHHELFST FSWDDQKVRQ LFIRKVYTIL LVQLLVTLAV VALFTFCDVV KDYVQANPGW YWASYAVFFA TYLTLACCSG PRRHFPWNLI LLTIFTLSMA YLTGMLSSYY NTTSVLLCLG ITALVCLSVT IFSFQTKFDF TSCHGVLFVL LMTLFFSGLL LAILLPFQYV PWLHAVYAVL GAGVFTLFLA FDTQLLMGNR RHSLSPEEYI FGALNIYLDI IYIFTFFLQL FGTNRE
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
35,036 Da
Sequence Positions
1-316
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 7; NC_005106.3 (138668122..138684087, complement). Location: 7q36
3D Structure
ModBase 3D Structure for O88407
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Faim2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Faim2. It may not necessarily be applicable to this product.

NCBI GI #
21426783
NCBI GeneID
246274
NCBI Accession #
NP_653357.1
UniProt Primary Accession #
O88407
UniProt Related Accession #
O88407
GenBank Nucleotide #
NM_144756.2
NCBI Official Full Name
protein lifeguard 2
NCBI Official Synonym Full Names
Fas apoptotic inhibitory molecule 2
NCBI Official Symbol
Faim2
NCBI Official Synonym Symbols
Lfg; NMP35
UniProt Protein Name
Protein lifeguard 2
UniProt Synonym Protein Names
Fas apoptotic inhibitory molecule 2; Neural membrane protein 35
Protein Family
Protein lifeguard
UniProt Gene Name
Faim2
UniProt Synonym Gene Names
Lfg; Lfg2; Nmp35
UniProt Entry Name
LFG2_RAT
NCBI Protein Information
protein lifeguard 2; neural membrane protein 35

NCBI Summary for Faim2

may mediate development and maintenance of the nervous system [RGD, Feb 2006]

UniProt Comments for Faim2

FAIM2: Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. Belongs to the BI1 family. LFG subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Apoptosis

Cellular Component: postsynaptic membrane; integral to membrane; cell junction; lipid raft

Biological Process: central nervous system development; cerebellar granular layer development; apoptosis; cerebellar Purkinje cell differentiation; regulation of neuron apoptosis; cerebellar Purkinje cell layer development; cerebellum development; negative regulation of neuron apoptosis
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Research Articles on Faim2

1. LFG mediated the FasL resistance of cerebellar granular cells to apoptosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Faim2 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with Faim2 and Neoplasms
 Brain Diseases Antibodies  >2 publications with Faim2 and Brain Diseases
 Stroke Antibodies  >2 publications with Faim2 and Stroke
 Cardiovascular Diseases Antibodies  >2 publications with Faim2 and Cardiovascular Diseases
 Fibrosarcoma Antibodies  >1 publications with Faim2 and Fibrosarcoma
 Necrosis Antibodies  >1 publications with Faim2 and Necrosis
 Atherosclerosis Antibodies  >1 publications with Faim2 and Atherosclerosis
 Coronary Disease Antibodies  >1 publications with Faim2 and Coronary Disease
 Drug Toxicity Antibodies  >1 publications with Faim2 and Drug Toxicity
 Brain Ischemia Antibodies  >1 publications with Faim2 and Brain Ischemia

Organs/Tissues associated with Faim2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with Faim2 and Brain
 Kidney Antibodies  >1 publications with Faim2 and Kidney
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