Potassium Voltage-Gated Channel Protein Shal (SHAL) Drosophila Melanogaster Recombinant Protein

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. May play a role in the nervous system and in the regulation of beating frequency in pacemaker cells.

Subunit structure: Heterotetramer of potassium channel proteins

By similarity. Interacts (via C-terminal dendritic targeting motif) with SIDL. Ref.6

Subcellular location: Membrane; Multi-pass membrane protein. Cell projection › dendrite. Perikaryon.

Tissue specificity: Co-expressed with SIDL in the nervous system. Ref.6

Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.

Miscellaneous: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities: Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Shal sub-subfamily. [View classification]