Human KCNQ2 Recombinant Protein – Cat# MBS1225997

Potassium Voltage-Gated Channel Subfamily KQT Member 2 (KCNQ2) Human Recombinant Protein

Name: KCNQ2 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1225997
Price: 1325 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1225997

MBS1225997 is a recombinant protein targeting KCNQ2. Also known as Recombinant Human Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1325 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2), Recombinant Protein

Full Product Name

Recombinant Human Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2) , partial

Product Gene Name

KCNQ2 recombinant protein

Sequence

GFALKVQEQH RQKHFEKRRN PAAGLIQSAW RFYATNLSRT DLHSTWQYYE RTVTVPMYSS QTQTYGASRL IPPLNQLELL RNLKSKSGLA FRKDPPPEPS PSKGSPCRGP LCGCCPGRSS QKVSLKDRVF SSPRGVAAKG KGSPQAQTVR RSPSADQSLE DSPSKVPKSW SFGDRSRARQ AFRIKGAASR QNSEEASLPG EDIVDDKSCP CEFVTEDLTP GLKVSIRAVC VMRFLVSKRK FKESLRPYDV MDVIEQYSAG HLDMLSRIKS LQSRVDQIVG RGPAITDKDR TKGPAEAELP EDPSMMGRLG KVEKQVLSME KKLDFLVNIY MQRMGIPPTE TEAYFGAKEP EPAPPYHSPE DSREHVDRHG CIVKIVRSSS STGQKNFSAP PAAPPVQCPP STSWQPQSHP RQGHGTSPVG DHGSLVRIPP PPAHERSLSA YGGGNRASME FLRQEDTPGC RPPEGNLRDS DTSISIPSVD HEELERSFSG FSISQSKENL DALNSCYAAV APCAKVRPYI AEGESDTDSD LCTPCGPPPR SATGEGPFGD VGWAGPRK

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

44,261 Da

Sequence Positions

315-872aa of O43526-1; partial of isoform 1

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

121200

3D Structure

ModBase 3D Structure for O43526

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of KCNQ2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNQ2. It may not necessarily be applicable to this product.

NCBI GI #

26051260

NCBI GeneID

3785

NCBI Accession #

NP_004509.2

UniProt Primary Accession #

O43526

UniProt Secondary Accession #

O43796; O75580; O95845; Q4VXP4; Q4VXR6; Q5VYT8; Q96J59; Q99454

UniProt Related Accession #

O43526

GenBank Nucleotide #

NM_004518.5

NCBI Official Full Name

potassium voltage-gated channel subfamily KQT member 2 isoform c

NCBI Official Synonym Full Names

potassium voltage-gated channel subfamily Q member 2

NCBI Official Symbol

KCNQ2

NCBI Official Synonym Symbols

EBN; BFNC; EBN1; ENB1; HNSPC; KV7.2; KCNA11

UniProt Protein Name

Potassium voltage-gated channel subfamily KQT member 2

UniProt Synonym Protein Names

KQT-like 2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2

Protein Family

Potassium voltage-gated channel subfamily

UniProt Gene Name

KCNQ2

NCBI Protein Information

potassium voltage-gated channel subfamily KQT member 2

NCBI Summary for KCNQ2

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for KCNQ2

Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873).

Research Articles on KCNQ2

1. Mutations in STXBP1 encoding the syntaxin binding protein 1 can produce a phenotype similar to that of KCNQ2 mutations

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KCNQ2 recombinant protein

Reference Product	PubMed Publications
KCNQ3 recombinant protein	>280 publications with KCNQ2 and KCNQ3
KCNQ1 recombinant protein	>72 publications with KCNQ2 and KCNQ1
KCNH6 recombinant protein	>4 publications with KCNQ2 and KCNH6
KCNH5 recombinant protein	>1 publications with KCNQ2 and KCNH5
KCNH2 recombinant protein	>1 publications with KCNQ2 and KCNH2

Pathways associated with KCNQ2 recombinant protein

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Cholinergic Synapse Pathway antibodies	Cholinergic Synapse Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Interaction Between L1 And Ankyrins Pathway antibodies	Interaction Between L1 And Ankyrins Pathway Diagram
L1CAM Interactions Pathway antibodies	L1CAM Interactions Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Potassium Channels Pathway antibodies	Potassium Channels Pathway Diagram
Voltage Gated Potassium Channels Pathway antibodies	Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with KCNQ2 recombinant protein

Disease Name	Pubmed Publications
Epilepsy Antibodies	>222 publications with KCNQ2 and Epilepsy
Nervous System Diseases Antibodies	>200 publications with KCNQ2 and Nervous System Diseases
Brain Diseases Antibodies	>177 publications with KCNQ2 and Brain Diseases
Epilepsy, Benign Neonatal Antibodies	>129 publications with KCNQ2 and Epilepsy, Benign Neonatal
Disease Models, Animal Antibodies	>17 publications with KCNQ2 and Disease Models, Animal
Cognition Disorders Antibodies	>4 publications with KCNQ2 and Cognition Disorders
Developmental Disabilities Antibodies	>4 publications with KCNQ2 and Developmental Disabilities
Inflammation Antibodies	>2 publications with KCNQ2 and Inflammation
Liver Diseases Antibodies	>2 publications with KCNQ2 and Liver Diseases
Learning Disorders Antibodies	>2 publications with KCNQ2 and Learning Disorders

Organs/Tissues associated with KCNQ2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>123 publications with KCNQ2 and Brain
Heart Antibodies	>21 publications with KCNQ2 and Heart
Intestine Antibodies	>4 publications with KCNQ2 and Intestine
Embryonic Tissue Antibodies	>4 publications with KCNQ2 and Embryonic Tissue
Eye Antibodies	>2 publications with KCNQ2 and Eye