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Serine/Threonine-Protein Kinase MARK1 (MARK1) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1227351

MBS1227351 is a recombinant protein targeting Mark1. Also known as Recombinant Rat Serine/threonine-protein kinase MARK1 (Mark1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1675 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Serine/threonine-protein kinase MARK1 (Mark1), Recombinant Protein
Full Product Name
Recombinant Rat Serine/threonine-protein kinase MARK1 (Mark1)
Product Gene Name
Mark1 recombinant protein
Sequence
MSARTPLPTV NERDTENHTS VDGYTETHIP PTKSSSRQNI PRCRNSITSA TDEQPHIGNY RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKCIVH RDLKAENLLL DADMNIKIAD FGFSNEFTVG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRVPFYM STDCENLLKK LLVLNPIKRG SLEQIMKDRW MNVGHEEEEL KPYSEPELDL NDAKRIDIMV TMGFARDEIN DALVSQKYDE VMATYILLGR KPPEFEGGES LSSGNLCQRS RPSSDLNNST LQSPAHLKVQ RSISANQKQR RFSDHAGPSI PPAVSYTKRP QANSVESEQK EEWDKDTARR LGSTTVGSKS EVTASPLVGP DRKKSSAGPS NNVYSGGSMT RRNTYVCERS TDRYAALQNG RDSSLTEMSA SSMSSTGSTV ASAGPSARPR HQKSMSTSGH PIKVTLPTIK DGSEAYRPGT AQRVPAASPS AHSISASTPD RTRFPRGSSS RSTFHGEQLR ERRSAAYSGP PASPSHDTAA LAHARRGTST GIISKITSKF VRRDPSEGEA SGRTDTARGS SGEPKDKEEG KEAKPRSLRF TWSMKTTSSM DPNDMVREIR KVLDANTCDY EQRERFLLFC VHGDARQDSL VQWEMEVCKL PRLSLNGVRF KRISGTSIAF KNIASKIANE LKL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
88,235 Da
Sequence Positions
1-793, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for O08678
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Mark1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Mark1. It may not necessarily be applicable to this product.

NCBI GI #
16758824
NCBI GeneID
117016
NCBI Accession #
NP_446399.1
UniProt Primary Accession #
O08678
UniProt Related Accession #
O08678
GenBank Nucleotide #
NM_053947.1
NCBI Official Full Name
serine/threonine-protein kinase MARK1
NCBI Official Synonym Full Names
microtubule affinity regulating kinase 1
NCBI Official Symbol
Mark1
UniProt Protein Name
Serine/threonine-protein kinase MARK1
UniProt Synonym Protein Names
MAP/microtubule affinity-regulating kinase 1
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
Mark1
NCBI Protein Information
serine/threonine-protein kinase MARK1

NCBI Summary for Mark1

phosphorylates the microtubule binding domain of microtubule-associated proteins and facilitates microtubule disruption; plays a role in microtubule dynamics [RGD, Feb 2006]

UniProt Comments for Mark1

Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
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Research Articles on Mark1

1. MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Mark1 recombinant protein

 Reference Product  PubMed Publications
 Stk11 recombinant protein  >4 publications with Mark1 and Stk11

Diseases associated with Mark1 recombinant protein

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >13 publications with Mark1 and Brain Diseases
 Mental Disorders Antibodies  >12 publications with Mark1 and Mental Disorders
 Neoplasms Antibodies  >9 publications with Mark1 and Neoplasms
 Necrosis Antibodies  >2 publications with Mark1 and Necrosis
 Liver Diseases Antibodies  >2 publications with Mark1 and Liver Diseases
 Cardiovascular Diseases Antibodies  >2 publications with Mark1 and Cardiovascular Diseases
 Drug Toxicity Antibodies  >2 publications with Mark1 and Drug Toxicity
 Vascular Diseases Antibodies  >2 publications with Mark1 and Vascular Diseases
 Inflammation Antibodies  >2 publications with Mark1 and Inflammation
 Stomach Neoplasms Antibodies  >2 publications with Mark1 and Stomach Neoplasms

Organs/Tissues associated with Mark1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >21 publications with Mark1 and Brain
 Kidney Antibodies  >5 publications with Mark1 and Kidney
 Heart Antibodies  >4 publications with Mark1 and Heart
 Ovary Antibodies  >3 publications with Mark1 and Ovary
 Prostate Antibodies  >1 publications with Mark1 and Prostate
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