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Gamma-Aminobutyric Acid Receptor Subunit Rho-3 (GABRR3) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1235903

MBS1235903 is a recombinant protein targeting GABRR3. Also known as Recombinant Human Gamma-aminobutyric acid receptor subunit rho-3 (GABRR3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Gamma-aminobutyric acid receptor subunit rho-3 (GABRR3), Recombinant Protein
Full Product Name
Recombinant Human Gamma-aminobutyric acid receptor subunit rho-3 (GABRR3)
Product Gene Name
GABRR3 recombinant protein
Product Synonym Gene Name
GABRR3
Product Synonym Names
Recombinant Gamma-aminobutyric acid receptor subunit rho-3 (GABRR3); Gamma-aminobutyric acid receptor subunit rho-3; GABA(A) receptor subunit rho-3 GABA(C) receptor
Sequence
ASNIKMTHQR CSSSMKQTCK QETRMKKDDS TKARPQKYEQ LLHIEDNDFA MRPGFGGSPV PVGIDVHVES IDSISETNMD FTMTFYLRHY WKDERLSFPS TANKSMTFDH RLTRKIWVPD IFFVHSKRSF IHDTTMENIM LRVHPDGNVL LSLRITVSAM CFMDFSRFPL DTQNCSLELE SYAYNEDDLM LYWKHGNKSL NTEEHMSLSQ FFIEDFSASS GLAFYSSTGW YNRLFINFVL RRHVFFFVLQ TYFPAILMVM LSWVSFWIDR RAVPARVSLG ITTVLTMSTI ITAVSASMPQ VSYLKAVDVY LWVSSLFVFL SVIEYAAVNY LTTVEERKQF KKTGKISRMY NIDAVQAMAF DGCYHDSEID MDQTSLSLNS EDFMRRKSIC SPSTDSSRIK RRKSLGGHVG RIILENNHVI DTYSRILFPI VYILFNLFYW GVYV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
54,272 Da
Sequence Positions
24-467
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 3; NC_000003.11 (97705527..97754148, complement). Location: 3q11.2
3D Structure
ModBase 3D Structure for A8MPY1
Species
Homo sapiens (Human)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GABRR3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GABRR3. It may not necessarily be applicable to this product.

NCBI GI #
157743288
NCBI GeneID
200959
NCBI Accession #
NP_001099050.1
UniProt Primary Accession #
A8MPY1
UniProt Secondary Accession #
Q9UIV9
UniProt Related Accession #
A8MPY1
GenBank Nucleotide #
NM_001105580.2
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit rho-3
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) A receptor, rho 3
NCBI Official Symbol
GABRR3
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit rho-3
UniProt Synonym Protein Names
GABA(A) receptor subunit rho-3; GABA(C) receptor
Protein Family
Gamma-aminobutyric acid receptor
UniProt Gene Name
GABRR3
UniProt Entry Name
GBRR3_HUMAN
NCBI Protein Information
gamma-aminobutyric acid receptor subunit rho-3; GABA(C) receptor; GABA(A) receptor subunit rho-3; gamma-aminobutyric acid (GABA) receptor, rho 3

NCBI Summary for GABRR3

The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP rs832032) that is predicted to inactivate the gene product. [provided by RefSeq, Jan 2012]
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UniProt Comments for GABRR3

GABRR3: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR3 sub-subfamily.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Transporter; Membrane protein, integral; Transporter, ion channel

Chromosomal Location of Human Ortholog: 3q11.2

Cellular Component: postsynaptic membrane; plasma membrane; cell junction

Molecular Function: protein domain specific binding; chloride channel activity; GABA-A receptor activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transmembrane transport; gamma-aminobutyric acid signaling pathway
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Research Articles on GABRR3

1. found no significant differences in either the frequencies of the GABRR1-M26V, GABRR1- H27R, GABRR2-T455M, and GABRR3-Y205X genotypes or in the frequencies of the allelic variants of these polymorphisms in patients with essential tremor

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GABRR3 recombinant protein

 Products by Pathway  Pathway Diagram
 GABA A (rho) Receptor Activation Pathway antibodies  GABA A (rho) Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with GABRR3 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with GABRR3 and Nervous System Diseases
 Movement Disorders Antibodies  >1 publications with GABRR3 and Movement Disorders

Organs/Tissues associated with GABRR3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >2 publications with GABRR3 and Eye
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