Herpesvirus 1 Thymidine Kinase (TK) Human Recombinant Protein

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.

The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene.McKnight S.L.Nucleic Acids Res. 8:5949-5964(1980) The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1.McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P.J. Gen. Virol. 69:1531-1574(1988) The three-dimensional structure of thymidine kinase from herpes simplex virus type 1.Wild K., Bohner T., Aubry A., Folkers G., Schulz G.E.FEBS Lett. 368:289-292(1995) Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir.Brown D.G., Visse R., Sandhu G., Davies A., Rizkallah P.J., Melitz C., Summers W.C., Sanderson M.R.Nat. Struct. Biol. 2:876-881(1995) The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue.Wild K., Bohner T., Folkers G., Schulz G.E.Protein Sci. 6:2097-2106(1997) Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.Champness J.N., Bennett M.S., Wien F., Visse R., Summers W.C., Herdewijn P., de Clerq E., Ostrowski T., Jarvest R.L., Sanderson M.R.3.0.CO;2-8>Proteins 32:350-361(1998) Structure to 1.9-A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor X-ray crystallographic comparison with binding of aciclovir.Bennett M.S., Wien F., Champness J.N., Batuwangala T., Rutherford T., Summers W.C., Sun H., Wright G., Sanderson M.R.FEBS Lett. 443:121-125(1999) Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography.Vogt J., Perozzo R., Pautsch A., Prota A., Schelling P., Pilger B., Folkers G., Scapozza L., Schulz G.E.3.0.CO;2-8>Proteins 41:545-553(2000)

Small volumes of TK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1237171 is a recombinant protein targeting TK. Also known as Recombinant Human herpesvirus 1 Thymidine kinase (TK). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.