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Lathosterol Oxidase (Sc5dl) (SC5D) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1238101

MBS1238101 is a recombinant protein targeting Sc5d. Also known as Recombinant Mouse Lathosterol oxidase (Sc5dl). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Lathosterol oxidase (Sc5dl), Recombinant Protein
Full Product Name
Recombinant Mouse Lathosterol oxidase (Sc5dl)
Product Gene Name
Sc5d recombinant protein
Product Synonym Gene Name
Sc5dl; Sc5d
Product Synonym Names
Recombinant Lathosterol oxidase (Sc5dl); Lathosterol oxidase EC= 1.14.21.6; C-5 sterol desaturase Delta(7)-sterol 5-desaturase Lathosterol 5-desaturase Sterol-C5-desaturase
Sequence
MDLVLSAADY YFFTPYVYPA TWPEDNIIRQ TISLLIVTNL GAYILYFFCA TLSYYFVYDH SLMKHPQFLK NQVSREIVFT VKSLPWISIP TVSLFLLELR GYSKLYDDIG DFPNGWIHLM VSVVSFLFFT DMLIYRIHRG LHHRLVYKRI HKPHHIWKIP TPFASHAFHP VDGFLQSLPY HIYPFVFPLH KVVYLGLYVL VNVWTISIHD GDFRVPQILR PFINGSAHHT DHHMFFDYNY GQYFTLWDRI GGSFKHPSSF EGKGPHSYVK NMTEKESNSF AENGCKGKKV SNGEFTKNK
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
35,062 Da
Sequence Positions
1-299
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 9; NC_000075.6 (42254177..42264300, complement). Location: 9; 9 B
3D Structure
ModBase 3D Structure for O88822
Species
Mus musculus (Mouse)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Sc5d recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Sc5d. It may not necessarily be applicable to this product.

NCBI GI #
6094244
NCBI GeneID
235293
NCBI Accession #
O88822.1
UniProt Primary Accession #
O88822
UniProt Related Accession #
O88822
NCBI Official Full Name
Lathosterol oxidase
NCBI Official Synonym Full Names
sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae)
NCBI Official Symbol
Sc5d
NCBI Official Synonym Symbols
Sc5dl; A830037K02; A830073K23Rik
UniProt Protein Name
Lathosterol oxidase
UniProt Synonym Protein Names
C-5 sterol desaturase; Delta(7)-sterol 5-desaturase; Lathosterol 5-desaturase; Sterol-C5-desaturase
Protein Family
Lathosterol oxidase
UniProt Gene Name
Sc5dl
UniProt Synonym Gene Names
Sc5d
UniProt Entry Name
SC5D_MOUSE
NCBI Protein Information
lathosterol oxidase; C-5 sterol desaturase; lathosterol 5-desaturase; delta(7)-sterol 5-desaturase

UniProt Comments for Sc5d

SC5DL: Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol. Defects in SC5DL are the cause of lathosterolosis (LATHST). This autosomal recessive disorder is characterized by a complex phenotype, including multiple congenital anomalies, mental retardation, and liver disease. Belongs to the sterol desaturase family.

Protein type: EC 1.14.21.6; Oxidoreductase; Membrane protein, multi-pass; Membrane protein, integral; Lipid Metabolism - steroid biosynthesis

Cellular Component: intracellular membrane-bound organelle; membrane; endoplasmic reticulum; integral to membrane

Molecular Function: C-5 sterol desaturase activity; lathosterol oxidase activity; iron ion binding; oxidoreductase activity

Biological Process: steroid metabolic process; sterol biosynthetic process; cholesterol biosynthetic process via lathosterol; lipid metabolic process; steroid biosynthetic process; fatty acid biosynthetic process
Show more

Research Articles on Sc5d

1. Data suggest that although cholesterol synthesis is impaired in both Dhcr7 mutant and Sc5d(-/-) embryonic brain, synthesis of nonsterol isoprenoids may be increased and thus contribute to Smith-Lemli-Opitz syndrome and lathosterolosis pathology.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Sc5d recombinant protein

 Products by Pathway  Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Sterols Biosynthesis Pathway antibodies  Sterols Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis I Pathway antibodies  Cholesterol Biosynthesis I Pathway Diagram

Organs/Tissues associated with Sc5d recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >19 publications with Sc5d and Liver
 Skin Antibodies  >6 publications with Sc5d and Skin
 Brain Antibodies  >3 publications with Sc5d and Brain
 Testis Antibodies  >1 publications with Sc5d and Testis
 Pancreas Antibodies  >1 publications with Sc5d and Pancreas
 Ovary Antibodies  >1 publications with Sc5d and Ovary
 Eye Antibodies  >1 publications with Sc5d and Eye
 Embryonic Tissue Antibodies  >1 publications with Sc5d and Embryonic Tissue
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